Spots Global Cancer Trial Database for leptomeningeal disease

Every month we try and update this database with for leptomeningeal disease cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
ANG1005 in Leptomeningeal Disease From Breast Cancer	NCT03613181	Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B...	ANG1005 Physician's Bes...	18 Years -	Angiochem Inc
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease	NCT05257967	EGFR Activating... Leptomeningeal ... Non Small Cell ...	Lumbar puncture...	18 Years -	British Columbia Cancer Agency
Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)	NCT05112549	Leptomeningeal ...	Nivolumab [Opdi...	18 Years -	University Hospital Tuebingen
Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System	NCT01596127	Leukemia Lymphoid Malign... Metastatic Mali...	Intrathecal Rit...	3 Years -	M.D. Anderson Cancer Center
Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26)	NCT05112549	Leptomeningeal ...	Nivolumab [Opdi...	18 Years -	University Hospital Tuebingen
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC	NCT03711422	Non-small Cell ... Leptomeningeal ... Central Nervous...	Afatinib Afatinib	21 Years -	National Cancer Centre, Singapore
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC	NCT03711422	Non-small Cell ... Leptomeningeal ... Central Nervous...	Afatinib Afatinib	21 Years -	National Cancer Centre, Singapore
ANG1005 in Leptomeningeal Disease From Breast Cancer	NCT03613181	Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B...	ANG1005 Physician's Bes...	18 Years -	Angiochem Inc
Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease	NCT05800275	Leptomeningeal ... Leptomeningeal ... HER2-positive M...	Tucatinib Oral ... Capecitabine ta... Trastuzumab Inj...	18 Years -	UNICANCER
RTA 744 Injection in Patients With Leptomeningeal Disease	NCT00512460	Neoplastic Meni... Solid Tumor Lymphoma Leukemia Brain Tumor	RTA 744	18 Years -	M.D. Anderson Cancer Center
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease	NCT03719768	Leptomeningeal ... Leptomeningeal ...	Avelumab Whole Brain Rad...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC	NCT03711422	Non-small Cell ... Leptomeningeal ... Central Nervous...	Afatinib Afatinib	21 Years -	National Cancer Centre, Singapore
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease	NCT03719768	Leptomeningeal ... Leptomeningeal ...	Avelumab Whole Brain Rad...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease	NCT04588545	HER2-positive B... Leptomeningeal ... Leptomeningeal ...	Radiation Thera... Pertuzumab Trastuzumab	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
ANG1005 in Leptomeningeal Disease From Breast Cancer	NCT03613181	Leptomeningeal ... Leptomeningeal ... Brain Metastase... HER2-negative B...	ANG1005 Physician's Bes...	18 Years -	Angiochem Inc
A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide	NCT05414123	Leptomeningeal ... Leptomeningeal ... Leptomeningeal ... Breast Cancer Non-Small Cell ...	CNSide	-	Biocept, Inc.
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD	NCT03501979	Metastatic Brea... Leptomeningeal ...	Tucatinib Trastuzumab Capecitabine	18 Years -	University of Alabama at Birmingham
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease	NCT03719768	Leptomeningeal ... Leptomeningeal ...	Avelumab Whole Brain Rad...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis	NCT06417710	Leptomeningeal ... Leptomeningeal ... Leptomeningeal ... Leptomeningeal ...	Neurological As...	18 Years -	University of Zurich
HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease	NCT05865990	Metastatic Brea... Advanced Non-Sm... Solid Tumor, Ad...	Patritumab deru...	18 Years -	MedSIR
Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma	NCT00338377	Melanoma	Dendritic Cell ... Cyclophosphamid... Fludarabine T-Cells Interleukin-2 Mesna Intrathecal T-C... Intrathecal Int...	12 Years -	M.D. Anderson Cancer Center
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease	NCT05257967	EGFR Activating... Leptomeningeal ... Non Small Cell ...	Lumbar puncture...	18 Years -	British Columbia Cancer Agency
A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)	NCT05809752	Leptomeningeal ... Triple Negative... HER2-positive B...	Dendritic Cell ...	18 Years -	H. Lee Moffitt Cancer Center and Research Institute
DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis	NCT00515788	Neoplastic Meni...	DepoCyt Temozolomide	18 Years -	M.D. Anderson Cancer Center

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