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Spots Global Cancer Trial Database for Integrated Cancer Repository for Cancer Research

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Interventions

Study Description

Brief Summary: The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.

Detailed Description: The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred \& Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the Pancreatic Cancer Collaborative Registry (PCCR) established in 2001, (ii) the Breast Cancer Collaborative Registry (BCCR) established in 2006, (iii) the Thyroid Cancer Collaborative Registry (TCCR) established in 2006, and (iv) the Great Plains Health Informatics Database (GPHID) established in 2011, to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment. At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal \& Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.

Eligibility

Minimum Age: 19 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Penrose Cancer Center, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Mercy Regional Medical Center, Durango, Colorado, United States

St. Anthony Hospital, Lakewood, Colorado, United States

Littleton Cancer Center, Littleton, Colorado, United States

Longmont Cancer Center, Longmont, Colorado, United States

Avista Cancer Center, Louisville, Colorado, United States

Parker Adventist Hospital, Parker, Colorado, United States

St. Mary Corwin Medical Center, Pueblo, Colorado, United States

St. Anthony North Cancer Center, Westminster, Colorado, United States

Bristol Health Beekley, Bristol, Connecticut, United States

Florida Hospital Memorial Medical Center, Daytona Beach, Florida, United States

Florida Hospital DeLand, DeLand, Florida, United States

Florida Hospital FISH, Orange City, Florida, United States

Florida Hospital Flagler, Palm Coast, Florida, United States

Tallahassee Memorial Hospital, Tallahassee, Florida, United States

Rush-Copley Cancer Care Center, Aurora, Illinois, United States

Trinity Medical Center, Moline, Illinois, United States

Rush-Copley Healthcare Center, Yorkville, Illinois, United States

Parkview Research Center, Fort Wayne, Indiana, United States

Community Health Network, Indianapolis, Indiana, United States

Community Cancer Center South, Indianapolis, Indiana, United States

Community Cancer Center North, Indianapolis, Indiana, United States

Community Howard Regional Hospital, Kokomo, Indiana, United States

Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa, United States

Genesis Medical Center, Davenport, Iowa, United States

Abben Cancer Center, Spencer, Iowa, United States

Covenant Medical Center, Inc, Waterloo, Iowa, United States

Saint Luke's Cancer Instititue - South, Overland Park, Kansas, United States

Tulane University, New Orleans, Louisiana, United States

Breast Care Specialists of Maine, Portland, Maine, United States

Northwest Hospital, Randallstown, Maryland, United States

William E Kahlert Regional Cancer Center, Westminster, Maryland, United States

Holyoke Medical Center, Holyoke, Massachusetts, United States

University of Michigan Health System, Ann Arbor, Michigan, United States

Riverwood Healthcare Center, Aitkin, Minnesota, United States

Essentia Health-St. Joseph's Medical Center, Brainerd, Minnesota, United States

Essentia Health - Duluth Clinic, Duluth, Minnesota, United States

St. Luke's Hospital of Duluth, Duluth, Minnesota, United States

Lake Region Healthcare, Fergus Falls, Minnesota, United States

Avera Cancer Institute- Marshall, Marshall, Minnesota, United States

Mercy Hospital - Joplin, Joplin, Missouri, United States

Saint Luke's Cancer Institute, East, Kansas City, Missouri, United States

Saint Luke's Cancer Institute, Kansas City, Missouri, United States

Saint Luke's Cancer Institute, Kansas City North, Kansas City, Missouri, United States

Saint Luke's Cancer Institute, Liberty, Liberty, Missouri, United States

Heartland Regional Medical Center dba Mosaic Life Care, Saint Joseph, Missouri, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Logan Health, Kalispell, Montana, United States

Providence St. Patrick Hospital Montana Cancer Center, Missoula, Montana, United States

Mary Lanning Healthcare, Morrison Cancer Center, Hastings, Nebraska, United States

Faith Regional Health Services, Carson Cancer Center, Norfolk, Nebraska, United States

Great Plains Regional Medical Center, North Platte, Nebraska, United States

Avera St. Anthony's Hospital, O'Neill, Nebraska, United States

Methodist Estabrook Cancer Center, Omaha, Nebraska, United States

Nebraska Methodist Health System, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Regional West Health Services, Scottsbluff, Nebraska, United States

C.R. Wood Cancer Center, Glens Falls Hospital, Glens Falls, New York, United States

Faxton St. Luke's Healthcare, Mohawk Valley, Utica, New York, United States

Cape Fear Valley Health System, Fayetteville, North Carolina, United States

Essentia Health, Fargo, North Dakota, United States

Trinity Hospital Cancer Care Center, Minot, North Dakota, United States

Aultman Alliance Community Hospital, Alliance, Ohio, United States

Aultman Hospital, Canton, Ohio, United States

University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Avera Medical Group Oncology and Hematology Aberdeen, Aberdeen, South Dakota, United States

Avera Cancer Institute, Mitchell, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Sanford Health, Sioux Falls, South Dakota, United States

Avera Cancer Center Yankton, Yankton, South Dakota, United States

Avera Sacred Heart Hospital, Yankton, South Dakota, United States

Yankton Medical Clinic, Yankton, South Dakota, United States

Rutland Regional Medical Center, Rutland, Vermont, United States

Mary Washington Hospital, Fredericksburg, Virginia, United States

Ascension St. Elizabeth Hospital, Appleton, Wisconsin, United States

Wheaton Franciscan Healthcare - Elmbrook Memorial Hospital, Brookfield, Wisconsin, United States

Wheaton Franciscan Healthcare, Reiman Cancer Care, Franklin, Wisconsin, United States

Bellin Memorial Hospital, Green Bay, Wisconsin, United States

Columbia St. Mary's, Mequon, Wisconsin, United States

Columbia St. Mary's, Milwaukee, Wisconsin, United States

Ascension Mercy Hospital, Oshkosh, Wisconsin, United States

Wheaton Franciscan Healthcare, All Saints, Racine, Wisconsin, United States

Wheaton Franciscan Healthcare, Wauwatosa Cancer Care, Wauwatosa, Wisconsin, United States

Contact Details

Name: Ken Cowan, MD

Affiliation: University of Nebraska

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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