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Brief Title: Integrated Cancer Repository for Cancer Research
Official Title: Integrated Cancer Repository for Cancer Research
Study ID: NCT02012699
Brief Summary: The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, high-risk individuals, and normal controls. The distinct characteristic of the iCaRe2 is its geographical coverage, with a significant percentage of small and rural hospitals and cancer centers. The iCaRe2 advances comprehensive studies of risk factors of cancer development and progression and enables the design of novel strategies for prevention, screening, early detection and personalized treatment of cancer. Centers with expertise in cancer epidemiology, genetics, biology, early detection, and patient care can collaborate by using the iCaRe2 as a platform for cohort and population studies.
Detailed Description: The integrated Cancer Repository for Cancer Research (iCaRe2 http://icare2project.org) is a unique sociotechnical resource for the collection and management of cancer and health-related data at the Fred \& Pamela Buffett Cancer Center at University of Nebraska Medical Center (UNMC). The iCaRe2 is a multi-center, semantically-interoperable and easily-customizable cancer data resource which is aimed at collecting, managing, mining and sharing the comprehensive, multi-dimensional cancer-related data on cancer patients and biospecimens (such as tumor specimens, germ line DNA, serum, urine, and plasma) collected from those individuals. The iCaRe2 provides: (i) a HIPAA compliant, secure, efficient and user-friendly mechanism for data and validation; (ii) utilization of standard vocabulary and data elements; and (iii) the ad-hoc data reporting capabilities. The iCaRe2 serves as a collaboration platform for studies (including clinical trials) performed in centers with expertise in cancer biology, pathology, epidemiology, genetics, early detection, and patient care. The iCaRe2 has been developed as an expansion of the biocomputing framework that initially included four multi-center collaborative registries: (i) the Pancreatic Cancer Collaborative Registry (PCCR) established in 2001, (ii) the Breast Cancer Collaborative Registry (BCCR) established in 2006, (iii) the Thyroid Cancer Collaborative Registry (TCCR) established in 2006, and (iv) the Great Plains Health Informatics Database (GPHID) established in 2011, to enroll subjects who have no personal history of cancer diagnosis at the time of enrollment. At present, this framework has been incrementally expanded to include the Thoracic Oncology Collaborative Registry (TOCR), GenitoUrinary Cancer Collaborative Registry (GUCARE), Head and Neck Cancer Collaborative Registry (HNCCR), Gastrointestinal \& Abdominal Cavity Cancer Collaborative Registry (GACCaRe), Central Nervous System Tumor Collaborative Registry (CTCR), Leukemia and Myeloid Neoplasm Registry (LEMN) , Gynecological Cancer Collaborative Registry (GCCR), Sarcoma Collaborative Registry (SARCR), Melanoma Collaborative Registry (MELCR), Plasma Cell Dyscrasias Collaborative Registry (PDCR), Neuroendocrine Collaborative Registry (NETR), and Auxiliary Cancer Registry (ACR). The iCaRe2 group elected to use a "confederation model", as opposed to a traditional registry or network model. It was felt that these latter models implied that the registry or network would assume control of an individual Center's database. The major advantages of a confederation model include the flexibility to use selected Centers for different research projects based on a Center's resources and expertise and the ability to have different strategies to address various research questions. It was also recognized that for this model to be successful, it is essential to have a standardized approach to data collection (patient information and biospecimen annotation) and reporting. A confederation would also encourage participation of any interested Center, irrespective of its size or location. A web-based registry iCaRe2 was developed and made available to any Center to participate in data collection and storage of cancer related data.
Minimum Age: 19 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Penrose Cancer Center, Colorado Springs, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Mercy Regional Medical Center, Durango, Colorado, United States
St. Anthony Hospital, Lakewood, Colorado, United States
Littleton Cancer Center, Littleton, Colorado, United States
Longmont Cancer Center, Longmont, Colorado, United States
Avista Cancer Center, Louisville, Colorado, United States
Parker Adventist Hospital, Parker, Colorado, United States
St. Mary Corwin Medical Center, Pueblo, Colorado, United States
St. Anthony North Cancer Center, Westminster, Colorado, United States
Bristol Health Beekley, Bristol, Connecticut, United States
Florida Hospital Memorial Medical Center, Daytona Beach, Florida, United States
Florida Hospital DeLand, DeLand, Florida, United States
Florida Hospital FISH, Orange City, Florida, United States
Florida Hospital Flagler, Palm Coast, Florida, United States
Tallahassee Memorial Hospital, Tallahassee, Florida, United States
Rush-Copley Cancer Care Center, Aurora, Illinois, United States
Trinity Medical Center, Moline, Illinois, United States
Rush-Copley Healthcare Center, Yorkville, Illinois, United States
Parkview Research Center, Fort Wayne, Indiana, United States
Community Health Network, Indianapolis, Indiana, United States
Community Cancer Center South, Indianapolis, Indiana, United States
Community Cancer Center North, Indianapolis, Indiana, United States
Community Howard Regional Hospital, Kokomo, Indiana, United States
Methodist Jennie Edmundson Hospital, Council Bluffs, Iowa, United States
Genesis Medical Center, Davenport, Iowa, United States
Abben Cancer Center, Spencer, Iowa, United States
Covenant Medical Center, Inc, Waterloo, Iowa, United States
Saint Luke's Cancer Instititue - South, Overland Park, Kansas, United States
Tulane University, New Orleans, Louisiana, United States
Breast Care Specialists of Maine, Portland, Maine, United States
Northwest Hospital, Randallstown, Maryland, United States
William E Kahlert Regional Cancer Center, Westminster, Maryland, United States
Holyoke Medical Center, Holyoke, Massachusetts, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
Riverwood Healthcare Center, Aitkin, Minnesota, United States
Essentia Health-St. Joseph's Medical Center, Brainerd, Minnesota, United States
Essentia Health - Duluth Clinic, Duluth, Minnesota, United States
St. Luke's Hospital of Duluth, Duluth, Minnesota, United States
Lake Region Healthcare, Fergus Falls, Minnesota, United States
Avera Cancer Institute- Marshall, Marshall, Minnesota, United States
Mercy Hospital - Joplin, Joplin, Missouri, United States
Saint Luke's Cancer Institute, East, Kansas City, Missouri, United States
Saint Luke's Cancer Institute, Kansas City, Missouri, United States
Saint Luke's Cancer Institute, Kansas City North, Kansas City, Missouri, United States
Saint Luke's Cancer Institute, Liberty, Liberty, Missouri, United States
Heartland Regional Medical Center dba Mosaic Life Care, Saint Joseph, Missouri, United States
Bozeman Health Deaconess Hospital, Bozeman, Montana, United States
Logan Health, Kalispell, Montana, United States
Providence St. Patrick Hospital Montana Cancer Center, Missoula, Montana, United States
Mary Lanning Healthcare, Morrison Cancer Center, Hastings, Nebraska, United States
Faith Regional Health Services, Carson Cancer Center, Norfolk, Nebraska, United States
Great Plains Regional Medical Center, North Platte, Nebraska, United States
Avera St. Anthony's Hospital, O'Neill, Nebraska, United States
Methodist Estabrook Cancer Center, Omaha, Nebraska, United States
Nebraska Methodist Health System, Omaha, Nebraska, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
Regional West Health Services, Scottsbluff, Nebraska, United States
C.R. Wood Cancer Center, Glens Falls Hospital, Glens Falls, New York, United States
Faxton St. Luke's Healthcare, Mohawk Valley, Utica, New York, United States
Cape Fear Valley Health System, Fayetteville, North Carolina, United States
Essentia Health, Fargo, North Dakota, United States
Trinity Hospital Cancer Care Center, Minot, North Dakota, United States
Aultman Alliance Community Hospital, Alliance, Ohio, United States
Aultman Hospital, Canton, Ohio, United States
University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Avera Medical Group Oncology and Hematology Aberdeen, Aberdeen, South Dakota, United States
Avera Cancer Institute, Mitchell, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Sanford Health, Sioux Falls, South Dakota, United States
Avera Cancer Center Yankton, Yankton, South Dakota, United States
Avera Sacred Heart Hospital, Yankton, South Dakota, United States
Yankton Medical Clinic, Yankton, South Dakota, United States
Rutland Regional Medical Center, Rutland, Vermont, United States
Mary Washington Hospital, Fredericksburg, Virginia, United States
Ascension St. Elizabeth Hospital, Appleton, Wisconsin, United States
Wheaton Franciscan Healthcare - Elmbrook Memorial Hospital, Brookfield, Wisconsin, United States
Wheaton Franciscan Healthcare, Reiman Cancer Care, Franklin, Wisconsin, United States
Bellin Memorial Hospital, Green Bay, Wisconsin, United States
Columbia St. Mary's, Mequon, Wisconsin, United States
Columbia St. Mary's, Milwaukee, Wisconsin, United States
Ascension Mercy Hospital, Oshkosh, Wisconsin, United States
Wheaton Franciscan Healthcare, All Saints, Racine, Wisconsin, United States
Wheaton Franciscan Healthcare, Wauwatosa Cancer Care, Wauwatosa, Wisconsin, United States
Name: Ken Cowan, MD
Affiliation: University of Nebraska
Role: PRINCIPAL_INVESTIGATOR