Spots Global Cancer Trial Database for lynch syndrome

Every month we try and update this database with for lynch syndrome cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance	NCT00313755	Colorectal Neop...	Narrow Band Ima...	18 Years -	London North West Healthcare NHS Trust
Uncertain Genetic Test Results for Lynch Syndrome	NCT01646112	HNPCC		18 Years - 100 Years	National Institutes of Health Clinical Center (CC)
Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland	NCT03124212	Hereditary Brea... Lynch Syndrome	CASCADE genetic...	18 Years -	University of Basel
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer	NCT00217737	Colon Mucinous ... Colon Signet Ri... Lynch Syndrome Stage IIA Colon... Stage IIB Colon... Stage IIC Colon...	Bevacizumab Fluorouracil Laboratory Biom... Leucovorin Calc... Oxaliplatin	18 Years -	National Cancer Institute (NCI)
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care	NCT03460483	Endometrial Ade... Endometrial Car... Lynch Syndrome Relatives	Genetic Counsel... Genetic Testing Laboratory Biom... Mutation Carrie...	18 Years -	Ohio State University Comprehensive Cancer Center
Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome	NCT05257057	Lynch Syndrome Endometrial Can... Endometrial Hyp... Mismatch Repair... Microsatellite ...	Immunohistochem...	18 Years - 99 Years	WellSpan Health
Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer	NCT00516230	Colonic Neoplas...		-	Samsung Medical Center
Atorvastatin ± Aspirin in Lynch Syndrome Syndrome	NCT04379999	Lynch Syndrome	Atorvastatin 20... Atorvastatin 20...	18 Years - 75 Years	Fox Chase Cancer Center
Men at High Genetic Risk for Prostate Cancer	NCT03805919	Prostatic Neopl...		30 Years - 75 Years	National Institutes of Health Clinical Center (CC)
Cancer Health Assessments Reaching Many	NCT03426878	Hereditary Canc...	Modified geneti... Traditional gen...	18 Years - 49 Years	Kaiser Permanente
Hereditary Colorectal and Associated Tumor Registry Study	NCT00633607	Lynch Syndrome FAP Hereditary Diff... Juvenile Polypo... Peutz-Jeghers S...	Research Regist...	8 Years - 100 Years	University of Pittsburgh
Telemedicine vs. Face-to-Face Cancer Genetic Counseling	NCT00609505	Hereditary Brea... Lynch Syndrome	Telemedicine Face-to-Face	18 Years -	Duke University
Prostate Cancer Genetic Risk Evaluation and Screening Study	NCT05129605	Prostatic Neopl... Prostate Cancer BRCA2 Mutation BRCA1 Mutation ATM Gene Mutati... MMR Mutation Lynch Syndrome Genetic Predisp...	Prostate cancer...	35 Years - 74 Years	Massachusetts General Hospital
Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorectal Cancer	NCT05495776	Colorectal Canc... Lynch Syndrome Hereditary Colo... MSI		18 Years -	State Scientific Centre of Coloproctology, Russian Federation
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members	NCT02194387	Body Mass Index... BRCA1 Gene Muta... BRCA2 Gene Muta... Breast Carcinom... Cancer Survivor Chronic Lymphoc... Fatigue Health Status U... Lynch Syndrome Ovarian Carcino... Overweight	Dietary Interve... Dietary Interve... Internet-Based ... Internet-Based ... Laboratory Biom... Questionnaire A... Telephone-Based... Telephone-Based...	18 Years -	M.D. Anderson Cancer Center
Family History Study on Cancer Risk	NCT04145388	Lynch Syndrome Colorectal Canc... Breast Cancer Ovarian Cancer Family Characte... Genetic Predisp...	online cancer r... Usual care	25 Years - 75 Years	Kaiser Permanente
Capsule Endoscopy to Screen for Small Bowel Neoplasia in Lynch Syndrome	NCT00898768	Lynch Syndrome Small Bowel Neo...	Capsule endosco...	35 Years - 70 Years	University Medical Center Groningen
Registry for Women Who Are At Risk Or May Have Lynch Syndrome	NCT00508573	Hereditary Nonp... Lynch Syndrome	Questionnaire	18 Years -	M.D. Anderson Cancer Center
The Cancer of the Pancreas Screening-5 CAPS5)Study	NCT02000089	Pancreas Cancer Peutz-Jeghers S... Gene Mutation Germline Mutati... Lynch Syndrome	Secretin MRI Tumor marker ge...	18 Years -	Johns Hopkins University
Linked Color Imaging Versus High-definition White Light Endoscopy for the Detection of Polyps in Patients With Lynch Syndrome (LCI-LYNCH)	NCT03344289	Lynch Syndrome Colonoscopy	Colonoscopy	18 Years -	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations	NCT02705846	Prostate Cancer	Observation of ...	18 Years -	Institute of Cancer Research, United Kingdom
Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention	NCT05677048	Gynecologic Can... Ovary Cancer Pancreatic Canc... Breast Cancer Lynch Syndrome Hereditary Brea... Colon Cancer Endometrial Can... Uterus Cancer	Free genetic te... IGNITE-TX Group IGNITE-TX and f...	18 Years -	M.D. Anderson Cancer Center
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care	NCT03460483	Endometrial Ade... Endometrial Car... Lynch Syndrome Relatives	Genetic Counsel... Genetic Testing Laboratory Biom... Mutation Carrie...	18 Years -	Ohio State University Comprehensive Cancer Center
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study	NCT05410977	Colorectal Carc... Lynch Syndrome	Biospecimen Col... Electronic Heal...	18 Years -	Mayo Clinic
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations	NCT02705846	Prostate Cancer	Observation of ...	18 Years -	Institute of Cancer Research, United Kingdom
Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy	NCT03631641	Colon Adenoma Colon Carcinoma Lynch Syndrome MLH1 Gene Mutat... MSH2 Gene Mutat...	Nivolumab	18 Years -	Ohio State University Comprehensive Cancer Center
Multi-Organ Screening Recommendations in Patients With Lynch Syndrome	NCT00582296	Lynch Syndrome	questionnaires,... questionnaires,...	18 Years -	Memorial Sloan Kettering Cancer Center
Scalable Communication Modalities for Returning Genetic Research Results	NCT04407611	Hereditary Brea... Lynch Syndrome	Online modality Genetic counsel...	40 Years -	Boston University
Faecal Microbiota Characterization in Lynch Syndrome (LS) Patients With or Without Colorectal Neoplasia	NCT04791644	Lynch Syndrome		18 Years - 75 Years	Assistance Publique - Hôpitaux de Paris
The GEOLynch Cohort Study	NCT03303833	Lynch Syndrome Neoplasms Hereditary Nonp... Colorectal Neop...	No intervention...	18 Years - 80 Years	Wageningen University
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria	NCT03046849	Lynch Syndrome	next-generation...	-	Second Affiliated Hospital, School of Medicine, Zhejiang University
Familial Colorectal Cancer Registry in Hispanics	NCT00927680	Colorectal Canc... Gastric Cancer Colorectal Neop... Colorectal Aden... Lynch Syndrome		15 Years -	University of Puerto Rico
Faecal Microbiota Characterization in Lynch Syndrome (LS) Patients With or Without Colorectal Neoplasia	NCT04791644	Lynch Syndrome		18 Years - 75 Years	Assistance Publique - Hôpitaux de Paris
A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome	NCT05411718	T Cells Colorectal Canc... Lynch Syndrome	Naproxen Aspirin	18 Years -	M.D. Anderson Cancer Center
Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome	NCT04508764	Hereditary Brea... Lynch Syndrome	Families Accele...	18 Years -	Washington University School of Medicine
DNA Adductomics for Colorectal Cancer Investigation	NCT04865601	Colorectal Canc... Familial Adenom... Hereditary Non-... Lynch Syndrome	resectomy of th...	18 Years -	University of Copenhagen
Adherence to Colon Cancer Screening (ACCS)	NCT02112747	Colon Cancer Rectal Cancer	Patient Navigat...	25 Years - 75 Years	Ohio State University Comprehensive Cancer Center
Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)	NCT03831698	Colorectal Canc... Lynch Syndrome	Omega-3 fatty a...	18 Years -	University of Kansas Medical Center
Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes	NCT02198092	Familial Adenom... Map Syndrome Lynch Syndrome Hnpcc Colorectal Canc...	Epi proColon Te...	18 Years -	University of Pennsylvania
Evaluating the Cologuard Test for Use in Lynch Syndrome	NCT04778566	Lynch Syndrome Colorectal Canc... Colonic Adenoma Colonic Polyp	Cologuard test	18 Years - 89 Years	Geisinger Clinic
Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance	NCT00313755	Colorectal Neop...	Narrow Band Ima...	18 Years -	London North West Healthcare NHS Trust
Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation	NCT04516083	Cancer Gene Mut... Lynch Syndrome Endometrial Can... Somatic Mutatio...	Mismatch repair...	-	RWJ Barnabas Health at Jersey City Medical Center
Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy	NCT03631641	Colon Adenoma Colon Carcinoma Lynch Syndrome MLH1 Gene Mutat... MSH2 Gene Mutat...	Nivolumab	18 Years -	Ohio State University Comprehensive Cancer Center
Survivorship in Lynch Syndrome Families	NCT01126840	Colorectal Canc...	Telephone Inter... Questionnaire	18 Years -	M.D. Anderson Cancer Center
Registry for Women Who Are At Risk Or May Have Lynch Syndrome	NCT00508573	Hereditary Nonp... Lynch Syndrome	Questionnaire	18 Years -	M.D. Anderson Cancer Center
Adherence to Colon Cancer Screening (ACCS)	NCT02112747	Colon Cancer Rectal Cancer	Patient Navigat...	25 Years - 75 Years	Ohio State University Comprehensive Cancer Center
Linked Color Imaging Versus High-definition White Light Endoscopy for the Detection of Polyps in Patients With Lynch Syndrome (LCI-LYNCH)	NCT03344289	Lynch Syndrome Colonoscopy	Colonoscopy	18 Years -	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting	NCT01582841	Colon Cancer Lynch Syndrome	MSI screening t...	18 Years -	Kaiser Permanente
MSI in Circulatory DNA of Endometrial Cancer	NCT03744962	Microsatellite ... Lynch Syndrome Endometrial Can... Circulating Tum...		-	Peking Union Medical College Hospital
The Cancer of the Pancreas Screening-5 CAPS5)Study	NCT02000089	Pancreas Cancer Peutz-Jeghers S... Gene Mutation Germline Mutati... Lynch Syndrome	Secretin MRI Tumor marker ge...	18 Years -	Johns Hopkins University
Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants	NCT04131062	Lynch Syndrome	Electronic Cons...	18 Years -	Geisinger Clinic
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study	NCT04500548	Constitutional ... Hematopoietic a... Lynch Syndrome Recurrent Lymph... Recurrent Malig... Recurrent Neuro... Recurrent Prima... Refractory Lymp... Refractory Mali... Refractory Neur... Refractory Prim... Xeroderma Pigme...	Biospecimen Col... Ipilimumab Nivolumab	12 Months - 25 Years	National Cancer Institute (NCI)
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations	NCT02705846	Prostate Cancer	Observation of ...	18 Years -	Institute of Cancer Research, United Kingdom
CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome	NCT05963191	Lynch Syndrome	Colorectal canc...	18 Years - 90 Years	French Society of Digestive Endoscopy
Tislelizumab for the Treatment of Recurrent Mismatch Repair Deficient Endometrial Cancer	NCT04906382	Lynch Syndrome Recurrent Endom... Recurrent Endom... Recurrent Uteri... Mismatch Repair... Recurrent Endom... Metastatic Endo...	Biopsy Carboplatin Paclitaxel Tislelizumab	18 Years -	Ohio State University Comprehensive Cancer Center
Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer	NCT02494791	Lynch Syndrome Endometrial Neo... Ovarian Neoplas... Colorectal Neop...	Questionnaire, ...	18 Years - 70 Years	University Health Network, Toronto
Molecular Screening for Lynch Syndrome in Denmark	NCT01845753	Colorectal Canc... Lynch Syndrome HNPCC	Observation	-	Vejle Hospital
Survivorship in Lynch Syndrome Families	NCT01126840	Colorectal Canc...	Telephone Inter... Questionnaire	18 Years -	M.D. Anderson Cancer Center
Molecular Screening for Lynch Syndrome in Southern Denmark	NCT01216930	Colorectal Canc... Lynch Syndrome HNPCC	Observation	-	Vejle Hospital
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients	NCT05078866	Lynch Syndrome	Adenoviral Tumo... Biospecimen Col... Endoscopic Biop... MVA Tumor-speci... Questionnaire A...	18 Years -	National Cancer Institute (NCI)
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome	NCT05419011	Lynch Syndrome	Adenovirus 5 CE... Biopsy Biospecimen Col... Colonoscopy Nogapendekin Al... Placebo Adminis... Questionnaire A...	18 Years -	National Cancer Institute (NCI)
Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome	NCT04920149	Lynch Syndrome Colon Cancer Colon Neoplasm	Mesalamine Placebo	30 Years -	Karolinska University Hospital
High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome.	NCT02951390	Lynch Syndrome	High-definition...	18 Years - 85 Years	Hospital Clinic of Barcelona
Survivorship in Lynch Syndrome Families	NCT01126840	Colorectal Canc...	Telephone Inter... Questionnaire	18 Years -	M.D. Anderson Cancer Center
Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome	NCT02052908	Lynch Syndrome	Laboratory Biom... Naproxen Placebo Adminis...	18 Years -	National Cancer Institute (NCI)
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair	NCT02912559	Colon Adenocarc... DNA Repair Diso... Lynch Syndrome Stage III Colon...	Atezolizumab Biospecimen Col... Computed Tomogr... Fluorouracil Leucovorin Calc... Magnetic Resona... Oxaliplatin Quality-of-Life...	12 Years -	National Cancer Institute (NCI)
Pancreas Registry and High Risk Registry	NCT02775461	Pancreas Cancer Pancreatitis Chronic Pancrea... Pancreatic Cyst Family History ... Genetic Mutatio...		18 Years -	Icahn School of Medicine at Mount Sinai
Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome	NCT04508764	Hereditary Brea... Lynch Syndrome	Families Accele...	18 Years -	Washington University School of Medicine
PeLear CCC: Proyecto Latino Contra Cancer Colorectal	NCT06426927	Colorectal Canc... Rectal Cancer Colon Cancer Colon Rectal Ca... Rectal Neoplasm... Colon Adenocarc... Hereditary Nonp...	Colorectal Canc...	18 Years -	University of North Carolina, Chapel Hill
Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome	NCT04920149	Lynch Syndrome Colon Cancer Colon Neoplasm	Mesalamine Placebo	30 Years -	Karolinska University Hospital
Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome	NCT05257057	Lynch Syndrome Endometrial Can... Endometrial Hyp... Mismatch Repair... Microsatellite ...	Immunohistochem...	18 Years - 99 Years	WellSpan Health
Pediatric Reporting of Adult-Onset Genomic Results	NCT03832985	Hereditary Brea... Lynch Syndrome Familial Hyperc...	Receive an adul... Receive a pedia... Control - No Re...	-	Geisinger Clinic
Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)	NCT03831698	Colorectal Canc... Lynch Syndrome	Omega-3 fatty a...	18 Years -	University of Kansas Medical Center
Inherited Cancer Early Diagnosis (ICED) Study	NCT06163365	Li Fraumeni Syn... Lynch Syndrome Hereditary Diff... Cowden Syndrome Peutz-Jeghers S... Familial Adenom... SMAD4 Gene Muta... MutYH-associate...		18 Years -	Royal Marsden NHS Foundation Trust
I-Scan For Colon Polyp Detection In HNPCC	NCT01823471	Hereditary Non-... HNPCC Lynch Syndrome	The use of I-sc...	18 Years -	Universitaire Ziekenhuizen KU Leuven
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma	NCT02359565	Constitutional ... Lynch Syndrome Malignant Gliom... Recurrent Brain... Recurrent Child... Recurrent Diffu... Recurrent Medul... Refractory Brai... Refractory Diff... Refractory Epen... Refractory Medu...	Biospecimen Col... Conventional Ma... Diffusion Tenso... Diffusion Weigh... Dynamic Contras... Dynamic Suscept... Magnetic Resona... Pembrolizumab	1 Year - 30 Years	National Cancer Institute (NCI)
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria	NCT03046849	Lynch Syndrome	next-generation...	-	Second Affiliated Hospital, School of Medicine, Zhejiang University
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer	NCT03047226	Lynch Syndrome	next-generation...	-	Second Affiliated Hospital, School of Medicine, Zhejiang University
Ohio Colorectal Cancer Prevention Initiative	NCT01850654	Lynch Syndrome Colorectal Canc...	LS tumor screen... Genetic testing Genetic Counsel... Biorepository Questionnaire	18 Years -	Ohio State University Comprehensive Cancer Center
High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome.	NCT02951390	Lynch Syndrome	High-definition...	18 Years - 85 Years	Hospital Clinic of Barcelona

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