Spots Global Cancer Trial Database for unresectable solid tumor

Every month we try and update this database with for unresectable solid tumor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination With Fulvestrant in Patients With Advanced Breast Cancer	NCT05216432	PIK3CA Mutation Solid Tumor, Ad... HER2-negative B... Breast Cancer Metastatic Brea... Advanced Breast... Unresectable So...	RLY-2608 Fulvestrant Palbociclib 125... Ribociclib 400m... Ribociclib 600m...	18 Years -	Relay Therapeutics, Inc.
A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumors	NCT03238027	Solid Tumor Metastatic Tumo... Locally Advance... Unresectable Ma...	Axatilimab Durvalumab	18 Years -	Syndax Pharmaceuticals
A Beta-only IL-2 ImmunoTherapY Study	NCT05086692	Advanced Solid ... Unresectable So... Clear Cell Rena... Triple Negative... Non-Small Cell ... Non-Small Cell ... Colorectal Canc... Gastric Cancer Cervical Cancer Basal Cell Carc... Bladder Cancer Merkel Cell Car... Squamous Cell C... Cutaneous Squam... Pleural Mesothe... Esophageal Canc... Endometrial Car... Solid Tumor Solid Tumor, Ad... MSI-H Solid Mal... Cancer With A H... Epithelial Ovar... Primary Periton... Gastroesophagea... Acral Melanoma Mucosal Melanom... Cutaneous Melan... DMMR Solid Mali... Fallopian Tube ... Ovarian Cancer MSI-H Cancer DMMR Cancer Pancreas Adenoc... Skin Cancer	MDNA11 Pembrolizumab	18 Years -	Medicenna Therapeutics, Inc.
A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors	NCT05464875	Gastrointestina... Unresectable So... Recurrent Metas...		18 Years -	First Affiliated Hospital, Sun Yat-Sen University
Pemigatinib + Afatinib in Advanced Refractory Solid Tumors	NCT06302621	Advanced Solid ... Unresectable So... Metastatic Soli... Cholangiocarcin...	Afatinib Pemigatinib	18 Years -	Massachusetts General Hospital
A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal Tumors	NCT05464875	Gastrointestina... Unresectable So... Recurrent Metas...		18 Years -	First Affiliated Hospital, Sun Yat-Sen University
First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors	NCT05759949	PIK3CA Mutation Solid Tumor, Ad... HER2-negative B... Breast Cancer Metastatic Brea... Advanced Breast... Unresectable So... Hormone Recepto...	RLY-5836 Fulvestrant Palbociclib Ribociclib Abemaciclib	18 Years -	Relay Therapeutics, Inc.
A Dose Escalation and Expansion Study of [177Lu]Lu-SN201 in Participants With Advanced Cancer	NCT06184035	Solid Tumor Metastatic Canc... Unresectable So... Recurrent Solid... Locally Advance... Refractory Canc...	[177Lu]Lu-SN201	18 Years -	Spago Nanomedical AB
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors	NCT06244771	Advanced Solid ... Solid Tumor, Ad... Unresectable So... Metastatic Soli... Non Small Cell ... Colorectal Canc... KRAS G12C Pancreatic Canc...	FMC-376	18 Years -	Frontier Medicines Corporation
COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases	NCT06185556	Colorectal Canc... Liver Metastase... Liver Metastasi... Unresectable So...	Irreversible el... Stereotactic bo...	18 Years -	Amsterdam UMC, location VUmc
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors	NCT06244771	Advanced Solid ... Solid Tumor, Ad... Unresectable So... Metastatic Soli... Non Small Cell ... Colorectal Canc... KRAS G12C Pancreatic Canc...	FMC-376	18 Years -	Frontier Medicines Corporation
First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors	NCT05759949	PIK3CA Mutation Solid Tumor, Ad... HER2-negative B... Breast Cancer Metastatic Brea... Advanced Breast... Unresectable So... Hormone Recepto...	RLY-5836 Fulvestrant Palbociclib Ribociclib Abemaciclib	18 Years -	Relay Therapeutics, Inc.

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