Spots Global Cancer Trial Database for malignant pleural effusion
Every month we try and update this database with for malignant pleural effusion cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma | NCT05278975 | Malignant Pleur... Malignant Pleur... Mesothelioma Mesotheliomas P... Mesothelioma; L... Pleural Effusio... | RSO-021 | 18 Years - | RS Oncology LLC | |
| Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System | NCT03414905 | Malignant Pleur... | Aspira Catheter Ultrasound | 18 Years - | Washington University School of Medicine | |
| Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer | NCT01661790 | Malignant Pleur... | Bevacizumab Cisplatin | 18 Years - 85 Years | Chinese PLA General Hospital | |
| Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer | NCT00005842 | Cancer | trastuzumab tipifarnib | 18 Years - | National Cancer Institute (NCI) | |
| Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer | NCT02122185 | Brenner Tumor Malignant Ascit... Malignant Pleur... Ovarian Clear C... Ovarian Endomet... Ovarian Mixed E... Ovarian Serous ... Ovarian Undiffe... Recurrent Fallo... Recurrent Ovari... Recurrent Ovari... Recurrent Prima... Stage IIIA Fall... Stage IIIA Ovar... Stage IIIA Ovar... Stage IIIA Prim... Stage IIIB Fall... Stage IIIB Ovar... Stage IIIB Ovar... Stage IIIB Prim... Stage IIIC Fall... Stage IIIC Ovar... Stage IIIC Ovar... Stage IIIC Prim... Stage IV Fallop... Stage IV Ovaria... Stage IV Ovaria... Stage IV Primar... | metformin hydro... placebo Chemotherapy | 18 Years - | University of Chicago | |
| Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion | NCT00313066 | Tuberculosis Tuberculous Ple... Malignant Pleur... Empyema | 18 Years - | Taichung Veterans General Hospital | ||
| Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion | NCT04792970 | Malignant Pleur... | Talc | 18 Years - | Duke University | |
| Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion | NCT02674243 | Malignant Pleur... | Iodopovidone so... Talc | 18 Years - | Chiang Mai University | |
| Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients | NCT02191540 | Malignant Pleur... | Abnoba Viscum F... | 20 Years - 80 Years | Abnoba Korea | |
| Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion | NCT02674243 | Malignant Pleur... | Iodopovidone so... Talc | 18 Years - | Chiang Mai University | |
| Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion | NCT02657460 | Malignant Pleur... | tumor derived m... cisplatin | 18 Years - 70 Years | Wuhan Union Hospital, China | |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites | NCT03736122 | Malignant Pleur... Malignant Ascit... | BSG-001 | 21 Years - | BioSyngen Pte Ltd | |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion | NCT05330065 | Malignant Pleur... | bevacizumab and... | 18 Years - | The First Affiliated Hospital of Zhengzhou University | |
| The 'MADe IT' Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer | NCT00215930 | Carcinoma, Non-... | Vinorelbine Docetaxel Gemcitabine Carboplatin | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| The Experiences of Patients Living With Malignant Pleural Effusions | NCT03235999 | Malignant Pleur... | 18 Years - | Gloucestershire Hospitals NHS Foundation Trust | ||
| Anemia Treatment for Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy | NCT00858364 | Non-Small Cell ... Anemia Cancer Lung Cancer | Darbepoetin alf... Placebo | 18 Years - | Amgen | |
| A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion | NCT02583282 | Malignant Pleur... | Doxycycline Iodopovidine | 18 Years - 80 Years | PGIMER | |
| Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter | NCT02649894 | Malignant Pleur... | Active Comparat... Experimental: S... | 18 Years - | CareFusion | |
| Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion | NCT00114205 | Metastatic Canc... | docetaxel therapeutic tho... | 18 Years - | National Cancer Institute (NCI) | |
| Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer | NCT00126581 | Lung Adenocarci... Lung Adenosquam... Malignant Peric... Malignant Pleur... Minimally Invas... Stage IIIB Lung... Stage IV Lung N... | Carboplatin Erlotinib Erlotinib Hydro... Paclitaxel | 18 Years - | National Cancer Institute (NCI) | |
| Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination | NCT04039126 | Malignant Pleur... | CHEMICAL PLEURO... CHEMICAL PLEURO... | 18 Years - 70 Years | University College Hospital, Ibadan | |
| AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion | NCT04322136 | Malignant Pleur... Respiratory Dis... Cancer | Pleurodesis via... Indwelling pleu... | 18 Years - | The University of Western Australia | |
| QUILT-2.013: A Trial of AMG 479 or AMG 102 in Combination With Platinum-based Chemotherapy as First-Line Treatment for Extensive Stage Small Cell Lung Cancer | NCT00791154 | Lung Cancer Small Cell Lung... Solid Tumors Extensive-stage... | AMG 479 Etoposide Placebo AMG 102 Carboplatin Cisplatin | 18 Years - | NantCell, Inc. | |
| Activity Behaviours in Patients With Malignant Pleural Effusion | NCT03482570 | Malignant Pleur... | ActiGraph | 18 Years - | The University of Hong Kong | |
| Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer | NCT02132884 | Malignant Peric... Malignant Pleur... Recurrent Non-s... Stage IIIB Non-... Stage IV Non-sm... | cytology specim... therapeutic pro... targeted therap... laboratory biom... | - | Fox Chase Cancer Center | |
| Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion | NCT04792970 | Malignant Pleur... | Talc | 18 Years - | Duke University | |
| A Multicenter Survey Study Into Patient Experience With Mobile Apps | NCT05130697 | Malignant Pleur... | eMPowEr App | - | National University of Ireland, Galway, Ireland | |
| A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion | NCT03597009 | Malignant Pleur... Stage IV Metast... Lung Cancer | Talimogene lahe... Nivolumab | 18 Years - 99 Years | UNC Lineberger Comprehensive Cancer Center | |
| Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study. | NCT04806412 | Malignant Pleur... Non-small Cell ... | meassurement of... | 18 Years - | Naestved Hospital | |
| Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer | NCT00408460 | Malignant Pleur... Recurrent Non-s... Stage IIIB Non-... Stage IV Non-sm... | imatinib mesyla... paclitaxel | 70 Years - | University of Washington | |
| Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions | NCT03449602 | Pleural Effusio... | Mini-thoracosco... Conventional ri... | 15 Years - 80 Years | PGIMER | |
| Talc Outpatient Pleurodesis With Indwelling Catheter | NCT03973957 | Pleural Effusio... Pleural Disease... Malignant Pleur... | Indwelling pleu... Fentanyl Citrat... Talc Slurry Drainage collec... | 18 Years - | The Cooper Health System | |
| Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer | NCT00052338 | Malignant Pleur... Recurrent Non-s... Stage IIIB Non-... Stage IV Non-sm... | gemcitabine hyd... carboplatin bortezomib laboratory biom... | 18 Years - | National Cancer Institute (NCI) | |
| Tunneled Pleural Catheter in Partially Entrapped Lung | NCT00637676 | Malignant Pleur... | VATS, Talc-Pleu... VATS, Talc-pleu... | 18 Years - | Heidelberg University | |
| Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia | NCT00899613 | Malignant Mesot... Metastatic Canc... | laboratory biom... study of high r... | - | National Cancer Institute (NCI) | |
| Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura | NCT00019825 | Esophageal Canc... Lung Cancer Malignant Mesot... Metastatic Canc... | decitabine | 18 Years - | National Cancer Institute (NCI) | |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites | NCT03736122 | Malignant Pleur... Malignant Ascit... | BSG-001 | 21 Years - | BioSyngen Pte Ltd | |
| Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer | NCT00005842 | Cancer | trastuzumab tipifarnib | 18 Years - | National Cancer Institute (NCI) | |
| Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients | NCT02191540 | Malignant Pleur... | Abnoba Viscum F... | 20 Years - 80 Years | Abnoba Korea | |
| Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer | NCT00042770 | Metastatic Canc... Pulmonary Compl... | talc dyspnea managem... | 18 Years - | Alliance for Clinical Trials in Oncology | |
| Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer | NCT00118183 | Adenocarcinoma ... Adenosquamous C... Large Cell Lung... Malignant Pleur... Recurrent Non-s... Squamous Cell L... Stage IIIB Non-... Stage IV Non-sm... | docetaxel cetuximab bortezomib | 18 Years - | National Cancer Institute (NCI) | |
| Quantitative Diaphragmatic Ultrasound Evaluation in Pleural Effusions : A Feasability Study | NCT04264325 | Malignant Pleur... Lung Neoplasms | diaphragmatic u... | 18 Years - | University Hospital, Strasbourg, France | |
| Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion | NCT04131231 | Lung Cancer Breast Cancer Malignant Pleur... | microparticles ... recombinant hum... | 18 Years - 80 Years | Peking Union Medical College | |
| Ultrasound-guided Biopsy of the Pleura as a Supplement to Extraction of Fluid in Patients With One-sided Fluid in the Pleura | NCT04236037 | Malignant Pleur... Exudative Pleur... | ultrasound-guid... Thoracentesis | 18 Years - | Naestved Hospital | |
| ILX-295501 in Treating Patients With Stage III or Stage IV Ovarian Cancer That Has Not Responded to Previous Treatment | NCT00005645 | Fallopian Tube ... Metastatic Canc... Ovarian Cancer Primary Periton... | ILX-295501 | 18 Years - 120 Years | Sanofi | |
| Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer | NCT00052338 | Malignant Pleur... Recurrent Non-s... Stage IIIB Non-... Stage IV Non-sm... | gemcitabine hyd... carboplatin bortezomib laboratory biom... | 18 Years - | National Cancer Institute (NCI) | |
| Talc in Treating Patients With Malignant Pleural Effusion | NCT00002622 | Metastatic Canc... | talc Talc | 18 Years - 120 Years | Alliance for Clinical Trials in Oncology | |
| Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients With Primary Lung Cancer | NCT00897143 | Lung Cancer Metastatic Canc... | microarray anal... mutation analys... flow cytometry immunologic tec... | - | Case Comprehensive Cancer Center | |
| Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion | NCT02429726 | Malignant Pleur... | rAdp53 Cisplatin rAdp53 plus cis... | 18 Years - | Shenzhen SiBiono GeneTech Co.,Ltd | |
| AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion | NCT04322136 | Malignant Pleur... Respiratory Dis... Cancer | Pleurodesis via... Indwelling pleu... | 18 Years - | The University of Western Australia | |
| Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma | NCT00821860 | Malignant Mesot... Metastatic Canc... | talc therapeutic tho... therapeutic vid... | 18 Years - | Papworth Hospital NHS Foundation Trust | |
| Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS | NCT03518788 | Malignant Pleur... | Pleur-X Pleurodesis | 18 Years - 80 Years | Ente Ospedaliero Cantonale, Bellinzona | |
| A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions | NCT04914598 | Malignant Pleur... | ENDOSTAR，cispla... Placebo , cispl... | 18 Years - | Jiangsu Simcere Pharmaceutical Co., Ltd. | |
| Pleural Carcinomatosis Tissue Banking | NCT04844827 | Pleural Effusio... | Conserving rout... | 18 Years - 110 Years | Hospices Civils de Lyon | |
| The First Therapeutic Intervention in Malignant Pleural Effusion Trial | NCT00896285 | Malignant Pleur... Pleural Effusio... | Large bore ches... Small bore ches... Large bore ches... Small bore ches... | 18 Years - | University of California, Davis | |
| Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE) | NCT05872126 | Malignant Pleur... Thoracic Cancer | VATS-Surgical p... Tube Drainage | 5 Years - 90 Years | Assiut University | |
| Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer | NCT02942043 | Malignant Pleur... | Bevacizumab | 18 Years - 75 Years | Peking University Cancer Hospital & Institute | |
| Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter | NCT02649894 | Malignant Pleur... | Active Comparat... Experimental: S... | 18 Years - | CareFusion | |
| Talc Outpatient Pleurodesis With Indwelling Catheter | NCT03973957 | Pleural Effusio... Pleural Disease... Malignant Pleur... | Indwelling pleu... Fentanyl Citrat... Talc Slurry Drainage collec... | 18 Years - | The Cooper Health System | |
| A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer. | NCT04233359 | Pleural Effusio... Pleural Effusio... Pleura; Exudate | Local anestheti... US-guided pleur... | 18 Years - | Naestved Hospital | |
| Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients With Primary Lung Cancer | NCT00897143 | Lung Cancer Metastatic Canc... | microarray anal... mutation analys... flow cytometry immunologic tec... | - | Case Comprehensive Cancer Center | |
| Prognostic Factors on Malignant Pleural Effusion | NCT03276715 | Pleural Effusio... Lung Cancer | 18 Years - | The University of Hong Kong | ||
| Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura | NCT00019825 | Esophageal Canc... Lung Cancer Malignant Mesot... Metastatic Canc... | decitabine | 18 Years - | National Cancer Institute (NCI) | |
| Defining the Clinical Potential of Mass Response as a Biomarker for Patient Tumor Sensitivity to Drugs | NCT04985357 | Stage III Breas... Stage IV Breast... Stage III Lung ... Stage IV Lung C... AML Multiple Myelom... Carcinoma Carcinoma, Panc... Carcinoma of Lu... Carcinoma, Non-... Carcinoma Breas... Carcinoma Prost... Carcinoma, Hepa... Carcinoma, Rena... Carcinoma, Neur... Carcinoma, Smal... Carcinoma, Ovar... Carcinoma Bladd... Carcinoma of Es... Carcinoma Cervi... Carcinoma, Thym... Carcinoma, Duct... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of Un... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of th... Carcinoma of th... Malignant Pleur... Malignant Ascit... Mesothelioma Cholangiocarcin... | 18 Years - | Travera Inc | ||
| Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment | NCT00752076 | NSCLC | cancer cell lin... | 18 Years - | National Taiwan University Hospital | |
| UNC Pleural Fluid Registry | NCT05620329 | Lung Cancer Lung Infection Breast Cancer Malignant Pleur... Empyema | 18 Years - | UNC Lineberger Comprehensive Cancer Center | ||
| Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer | NCT00231465 | Non-Small Cell ... | docetaxel (Taxo... ZD1839 | 70 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites | NCT03736122 | Malignant Pleur... Malignant Ascit... | BSG-001 | 21 Years - | BioSyngen Pte Ltd | |
| UNC Pleural Fluid Registry | NCT05620329 | Lung Cancer Lung Infection Breast Cancer Malignant Pleur... Empyema | 18 Years - | UNC Lineberger Comprehensive Cancer Center | ||
| Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions | NCT00066404 | Cancer | recombinant ade... | 18 Years - 120 Years | Abramson Cancer Center at Penn Medicine | |
| Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer | NCT00508144 | Lung Cancer | Alimta | 18 Years - | M.D. Anderson Cancer Center | |
| Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer | NCT00508144 | Lung Cancer | Alimta | 18 Years - | M.D. Anderson Cancer Center | |
| Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System | NCT03414905 | Malignant Pleur... | Aspira Catheter Ultrasound | 18 Years - | Washington University School of Medicine | |
| Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer | NCT02054052 | Non-small Cell ... Malignant Pleur... | Bevacizumab | 18 Years - | Guangzhou Medical University | |
| Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions | NCT00066404 | Cancer | recombinant ade... | 18 Years - 120 Years | Abramson Cancer Center at Penn Medicine | |
| AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer | NCT00528645 | Extensive Stage... Lung Metastases Malignant Pleur... Recurrent Small... | saracatinib | 18 Years - | National Cancer Institute (NCI) | |
| A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion | NCT05923515 | Malignant Pleur... | JMKX000197 | 18 Years - 75 Years | Jemincare | |
| The Experiences of Patients Living With Malignant Pleural Effusions | NCT03235999 | Malignant Pleur... | 18 Years - | Gloucestershire Hospitals NHS Foundation Trust | ||
| Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer | NCT06016179 | Malignant Pleur... Malignant Ascit... | Tocilizumab | 18 Years - 89 Years | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | |
| A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC | NCT03987087 | Malignant Pleur... Nonsmall Cell L... | Radiation Chemotherapy | 18 Years - 80 Years | Guizhou Medical University |
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