Spots Global Cancer Trial Database for metastatic colorectal adenocarcinoma

Every month we try and update this database with for metastatic colorectal adenocarcinoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Bevacizumab in Combination With First-Line Chemotherapy in Patients Aged 75 Years of Older With Metastatic Colorectal Adenocarcinoma (Prodige20)	NCT01900717	Metastatic Colo...	LV5FU2 simplifi... LV5FU2 simplifi...	75 Years -	Centre Hospitalier Universitaire Dijon
Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer	NCT04362839	Advanced Colon ... Metastatic Colo... Metastatic Colo... Metastatic Colo... Metastatic Rect... Stage III Colon... Stage III Recta... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Rect... Stage IV Colon ... Stage IV Colore... Stage IV Rectal... Stage IVA Colon... Stage IVA Color... Stage IVA Recta... Stage IVB Colon... Stage IVB Color... Stage IVB Recta... Stage IVC Colon... Stage IVC Color... Stage IVC Recta...	Ipilimumab Nivolumab Regorafenib	18 Years -	City of Hope Medical Center
Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Metastatic Colorectal Adenocarcinoma	NCT01639131	Metastatic Colo...	Gemcitabine Docetaxel Filgrastim or P...	18 Years -	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders	NCT04729322	Metastatic Colo... Metastatic Smal... Stage IV Colore... Stage IV Small ... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Biopsy Fecal Microbiot... Fecal Microbiot... Metronidazole Neomycin Nivolumab Pembrolizumab Questionnaire A... Vancomycin	18 Years -	M.D. Anderson Cancer Center
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study	NCT05673148	Metastatic Colo... Stage IV Colore...	Stereotactic Ab... Resection Microwave Ablat... Chemotherapy Computed Tomogr... Magnetic Resona... Positron Emissi...	18 Years -	Alliance for Clinical Trials in Oncology
Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations	NCT06043713	Metastatic Colo... Metastatic Lung... Metastatic Panc... Stage IV Colore... Stage IV Lung C... Stage IV Pancre...	Bendamustine Biopsy Biospecimen Col... Computed Tomogr... Cyclophosphamid... Echocardiograph... Fludarabine Leukapheresis Magnetic Resona... Multigated Acqu... Positron Emissi... T-cell Receptor...	18 Years -	Fred Hutchinson Cancer Center
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer	NCT03043313	Metastatic Colo...	Trastuzumab Tucatinib	18 Years -	Seagen Inc.
Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer	NCT04362839	Advanced Colon ... Metastatic Colo... Metastatic Colo... Metastatic Colo... Metastatic Rect... Stage III Colon... Stage III Recta... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Rect... Stage IV Colon ... Stage IV Colore... Stage IV Rectal... Stage IVA Colon... Stage IVA Color... Stage IVA Recta... Stage IVB Colon... Stage IVB Color... Stage IVB Recta... Stage IVC Colon... Stage IVC Color... Stage IVC Recta...	Ipilimumab Nivolumab Regorafenib	18 Years -	City of Hope Medical Center
Efficacy and Safety of Everolimus in Patients With Metastatic Colorectal Cancer Who Have Failed Prior Targeted Therapy and Chemotherapy	NCT00419159	Colorectal Canc...	Everolimus (RAD...	18 Years -	Novartis
Metastatic Left Colon and Rectal Cancer Treatment With Anti_EGFR Targeted Therapy	NCT06083974	Metastatic Colo...		18 Years - 75 Years	Assiut University
Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer	NCT04511039	Advanced Malign... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Locally Advance... Locally Advance... Metastatic Colo... Metastatic Gast... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Trifluridine an... Talazoparib Tos...	18 Years -	Roswell Park Cancer Institute
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer	NCT03043313	Metastatic Colo...	Trastuzumab Tucatinib	18 Years -	Seagen Inc.
Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study	NCT02997228	Metastatic Colo... Stage IV Colore...	Atezolizumab Bevacizumab Biospecimen Col... Computed Tomogr... Fluorouracil Leucovorin Magnetic Resona... Oxaliplatin Positron Emissi... Quality-of-Life... Questionnaire A...	18 Years -	National Cancer Institute (NCI)
A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer	NCT05130060	Metastatic Colo... Metastatic Colo... Metastatic Colo... Metastatic Micr... Metastatic Micr... Metastatic Rect... Microsatellite ... Stage IV Colore... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Colorectal Canc... Trifluridine an...	18 Years -	Mayo Clinic
Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC	NCT06195670	CRC Metastatic Colo... Metastatic Colo...	Experimental Active Comparat...	18 Years - 85 Years	Zhejiang Cancer Hospital
Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer	NCT02600949	Metastatic Colo... Metastatic Panc... Stage IV Colore... Stage IV Pancre... Stage IVA Color... Stage IVB Color...	Imiquimod Pembrolizumab Sotigalimab Synthetic Tumor... Computed Tomogr... Magnetic Resona...	18 Years -	M.D. Anderson Cancer Center
Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer	NCT04044430	Metastatic Colo... Metastatic Colo... Metastatic Micr... Metastatic Rect... Stage III Colon... Stage III Color... Stage III Recta... Stage IIIA Colo... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Colo... Stage IIIC Rect... Stage IV Colon ... Stage IV Colore... Stage IV Rectal... Stage IVA Colon... Stage IVA Color... Stage IVA Recta... Stage IVB Colon... Stage IVB Color... Stage IVB Recta... Stage IVC Colon... Stage IVC Color... Stage IVC Recta...	Binimetinib Encorafenib Nivolumab Questionnaire A...	18 Years -	University of California, San Francisco
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study	NCT05673148	Metastatic Colo... Stage IV Colore...	Stereotactic Ab... Resection Microwave Ablat... Chemotherapy Computed Tomogr... Magnetic Resona... Positron Emissi...	18 Years -	Alliance for Clinical Trials in Oncology
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders	NCT04729322	Metastatic Colo... Metastatic Smal... Stage IV Colore... Stage IV Small ... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Biopsy Fecal Microbiot... Fecal Microbiot... Metronidazole Neomycin Nivolumab Pembrolizumab Questionnaire A... Vancomycin	18 Years -	M.D. Anderson Cancer Center
CAPRI 2 GOIM Study: Investigate the Efficacy and Safety of a Bio-marker Driven Cetuximab-based Treatment Regimen	NCT05312398	Metastatic Colo...	Cetuximab FOLFIRI FOLFOX regimen Irinotecan	18 Years -	University of Campania "Luigi Vanvitelli"
Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer	NCT06336902	Metastatic Colo... Stage IV Colore...	Balstilimab Biospecimen Col... Botensilimab Computed Tomogr... Dietary Interve... Magnetic Resona... Vitamin C	18 Years -	University of Southern California
Efficacy and Safety of Everolimus in Patients With Metastatic Colorectal Cancer Who Have Failed Prior Targeted Therapy and Chemotherapy	NCT00419159	Colorectal Canc...	Everolimus (RAD...	18 Years -	Novartis
Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer	NCT04511039	Advanced Malign... Clinical Stage ... Clinical Stage ... Clinical Stage ... Clinical Stage ... Locally Advance... Locally Advance... Metastatic Colo... Metastatic Gast... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Pathologic Stag... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Postneoadjuvant... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Trifluridine an... Talazoparib Tos...	18 Years -	Roswell Park Cancer Institute
Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer	NCT02600949	Metastatic Colo... Metastatic Panc... Stage IV Colore... Stage IV Pancre... Stage IVA Color... Stage IVB Color...	Imiquimod Pembrolizumab Sotigalimab Synthetic Tumor... Computed Tomogr... Magnetic Resona...	18 Years -	M.D. Anderson Cancer Center
Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer	NCT03087071	EGFR NP_005219.... KRAS Gene Mutat... MAP2K1 Gene Mut... Metastatic Colo... Refractory Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color...	Laboratory Biom... Panitumumab Trametinib	18 Years -	M.D. Anderson Cancer Center
Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer	NCT04117945	BRAF V600E Nega... KRAS Gene Mutat... Locally Advance... Metastatic Colo... NRAS Gene Mutat... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Cetuximab Irinotecan Panitumumab Regorafenib	18 Years -	Academic and Community Cancer Research United
Tucatinib Combined With Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study	NCT05356897	Metastatic Colo... Metastatic Colo... Metastatic Rect... Stage IV Colon ... Stage IV Colore... Stage IV Rectal...	Trastuzumab Trifluridine an... Tucatinib	18 Years -	Academic and Community Cancer Research United
Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study	NCT02997228	Metastatic Colo... Stage IV Colore...	Atezolizumab Bevacizumab Biospecimen Col... Computed Tomogr... Fluorouracil Leucovorin Magnetic Resona... Oxaliplatin Positron Emissi... Quality-of-Life... Questionnaire A...	18 Years -	National Cancer Institute (NCI)
Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer	NCT04362839	Advanced Colon ... Metastatic Colo... Metastatic Colo... Metastatic Colo... Metastatic Rect... Stage III Colon... Stage III Recta... Stage IIIA Colo... Stage IIIA Rect... Stage IIIB Colo... Stage IIIB Rect... Stage IIIC Colo... Stage IIIC Rect... Stage IV Colon ... Stage IV Colore... Stage IV Rectal... Stage IVA Colon... Stage IVA Color... Stage IVA Recta... Stage IVB Colon... Stage IVB Color... Stage IVB Recta... Stage IVC Colon... Stage IVC Color... Stage IVC Recta...	Ipilimumab Nivolumab Regorafenib	18 Years -	City of Hope Medical Center
Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer	NCT03087071	EGFR NP_005219.... KRAS Gene Mutat... MAP2K1 Gene Mut... Metastatic Colo... Refractory Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color...	Laboratory Biom... Panitumumab Trametinib	18 Years -	M.D. Anderson Cancer Center
Rintatolimod and Pembrolizumab for the Treatment of Refractory Metastatic or Unresectable Colorectal Cancer	NCT04119830	Metastatic Colo... Microsatellite ... Mismatch Repair... Refractory Colo... Stage III Color... Stage IIIA Colo... Stage IIIB Colo... Stage IIIC Colo... Stage IV Colore... Stage IVA Color... Stage IVB Color... Stage IVC Color... Unresectable Co...	Pembrolizumab Questionnaire A... Rintatolimod	18 Years -	Roswell Park Cancer Institute
Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders	NCT04729322	Metastatic Colo... Metastatic Smal... Stage IV Colore... Stage IV Small ... Stage IVA Color... Stage IVB Color... Stage IVC Color...	Biopsy Fecal Microbiot... Fecal Microbiot... Metronidazole Neomycin Nivolumab Pembrolizumab Questionnaire A... Vancomycin	18 Years -	M.D. Anderson Cancer Center

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