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Spots Global Cancer Trial Database for The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

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Interventions

Radiation therapy

Study Description

Brief Summary: The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpose to improve patients' survival, local, and regional tumor control and quality of life.

Detailed Description: Rationale: Radiation therapy has become indispensable in cancer treatment. However, it is associated with severe side effects. Innovation in radiation therapy has resulted in the development of MR-guided radiation therapy (MRGRT) which allows high precision radiotherapy under real time MR visualization. High precision MRGRT has the potential of dose escalation and margin reduction and may potentially lead to higher cure rates and less toxicity. MRGRT can be delivered by the MRI guided Linear Accelerator (MR-Linac) which integrates a state-of-the-art linear accelerator, 1.5T diagnostic quality MRI and an online adaptive workflow. Objective: The Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-Linac Study (MOMENTUM) aims to accelerate the technical and clinical development of Anatomic and Biologic MRGRT and facilitate the evidence-based introduction of the MR-Linac into clinical practice. In MOMENTUM, technical and clinical data are gathered in order to optimize software, evaluate treatment outcomes, toxicities and progression free, disease free, and overall survival per disease site, and create a repository of anatomical and biological MR sequences to develop new features. Study design: A multi-institutional, international observational cohort study. Study population: Cancer patients ≥ 18 years receiving treatment and/or imaging on an MR-Linac machine are eligible for enrollment. Main study parameters/endpoints: MOMENTUM will collect technical and clinical patient data. The technical patient data is defined as data generated by (the use of) the MR-Linac and will include data collection during scans performed during routine care as well as research MRIs. Clinical data will be categorized into six classes: demographic, disease characteristics, treatment classifiers, toxicity outcomes, cancer control outcomes and PROs.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Allegheny Health Network, Pittsburgh, Pennsylvania, United States

Md Anderson Cancer Center, Houston, Texas, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Austin Health - Olivia Newton-John Cancer Wellness and Research Centre, Melbourne, , Australia

Insitut Jules Bordet, Brussel, , Belgium

Sunnybrook Health Sciences Centre/Odette Cancer Centre, Toronto, Ontario, Canada

University Health Network - Princess Margaret Cancer Center, Toronto, , Canada

Odense Universitetshospital, Odense, Funen, Denmark

Universitätsklinikum Tübingen, Tübingen, , Germany

Università degli Studi di Brescia, Brescia, , Italy

IRCCS Ospedale Sacro Cuore Don Calabria, Negrar, , Italy

Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, , Netherlands

Radiotherapiegroep, Deventer, , Netherlands

Radiotherapeutisch Instituut Friesland (RIF), Leeuwarden, , Netherlands

Radboud UMC, Nijmegen, , Netherlands

University Medical Center Utrecht, Utrecht, , Netherlands

The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, London, , United Kingdom

The Christie National Health Service Foundation Trust, Manchester, , United Kingdom

Contact Details

Name: Helena M Verkooijen, Prof, Dr

Affiliation: Universitair Medical Centre Utrecht

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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