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Spots Global Cancer Trial Database for lomustine

Every month we try and update this database with for lomustine cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study titleNCT IDConditionsInterventionsEligibilityOrganizationLink
Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic OligodendrogliomaNCT00002840
Brain and Centr...
lomustine
procarbazine hy...
vincristine sul...
radiation thera...
16 Years - 69 YearsEuropean Organisation for Research and Treatment of Cancer - EORTC
Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary GlioblastomaNCT00761280
Anaplastic Astr...
Glioblastoma
trabedersen
temozolomide
Drug delivery s...
Placement of Dr...
carmustine
lomustine
18 Years - 70 YearsIsarna Therapeutics GmbH
A Dose-Escalation Study in Participants With Recurrent Malignant GliomaNCT01682187
Glioma
LY2157299
Lomustine
18 Years - Eli Lilly and Company
Bevacizumab and Lomustine for Recurrent GBMNCT01290939
Glioblastoma Mu...
Cognition Disor...
Disability Eval...
bevacizumab
lomustine
DNA methylation...
laboratory biom...
cognitive asses...
quality-of-life...
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
Enzastaurin Versus Lomustine in GlioblastomaNCT00295815
Glioblastoma
enzastaurin
lomustine
18 Years - Eli Lilly and Company
Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)NCT01067469
Brain Cancer
Glioblastoma
Standard Dose B...
Low Dose Bevaci...
Lomustine
18 Years - M.D. Anderson Cancer Center
Bevacizumab and Lomustine for Recurrent GBMNCT01290939
Glioblastoma Mu...
Cognition Disor...
Disability Eval...
bevacizumab
lomustine
DNA methylation...
laboratory biom...
cognitive asses...
quality-of-life...
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
Regorafenib in Relapsed GlioblastomaNCT02926222
Glioblastoma Mu...
Regorafenib
Lomustine
18 Years - Istituto Oncologico Veneto IRCCS
Combination Chemotherapy in Treating Children With Progressive Brain TumorsNCT00002944
Brain Tumors
Central Nervous...
carboplatin
lomustine
procarbazine hy...
thioguanine
vincristine sul...
- 9 YearsChildren's Oncology Group
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent GlioblastomaNCT04421378
Glioblastoma Mu...
Selinexor
Temozolomide (T...
Lomustine (CCNU...
Standard Fracti...
Bevacizumab
TTField
Carmustine
18 Years - Karyopharm Therapeutics Inc
Anti-Lag-3 (Relatlinib) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent GlioblastomaNCT06325683
Recurrent Gliob...
Biopsy
Biospecimen Col...
Lomustine
Magnetic Resona...
Nivolumab
Relatlimab
Surgical Proced...
18 Years - National Cancer Institute (NCI)
Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With OligodendrogliomaNCT00003101
Brain and Centr...
filgrastim
busulfan
lomustine
procarbazine hy...
thiotepa
vincristine sul...
autologous bone...
peripheral bloo...
18 Years - Memorial Sloan Kettering Cancer Center
Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Metastatic Medulloblastoma Who Have Undergone SurgeryNCT00276666
Brain and Centr...
cisplatin
lomustine
vincristine sul...
adjuvant therap...
radiation thera...
3 Years - 21 YearsNational Cancer Institute (NCI)
Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central Nervous System LymphomaNCT00003929
Lymphoma
filgrastim
lomustine
procarbazine hy...
radiation thera...
- Case Comprehensive Cancer Center
Ph 1/2 CTO With Lomustine for Bevacizumab-Naive Recurrent GliomaNCT01989052
Malignant Gliom...
CTO
Lomustine
18 Years - Duke University
Lomustine in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerNCT00293280
Lung Cancer
lomustine
18 Years - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or GliosarcomaNCT05017610
Recurrent Gliob...
Recurrent Glios...
Liothyronine
Lomustine
Methimazole
18 Years - Emory University
Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma MultiformeNCT01934361
Recurrent Gliob...
buparlisib
carboplatin
lomustine
placebo
18 Years - Novartis
Bevacizumab and Lomustine for Recurrent GBMNCT01290939
Glioblastoma Mu...
Cognition Disor...
Disability Eval...
bevacizumab
lomustine
DNA methylation...
laboratory biom...
cognitive asses...
quality-of-life...
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing LossNCT05382338
Medulloblastoma
Cisplatin
Cyclophosphamid...
Lomustine
Mesna
Quality-of-Life...
Radiation Thera...
Sodium Thiosulf...
Survey Administ...
Vincristine
3 Years - 21 YearsChildren's Oncology Group
Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed MedulloblastomaNCT00031590
Brain Tumors
Central Nervous...
Medulloblastoma
Cisplatin
Cyclophosphamid...
Etoposide
Lomustine
Vincristine
Craniospinal Ra...
3 Years - 30 YearsChildren's Hospital of Philadelphia
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade GliomasNCT02343406
Glioblastoma
Depatuxizumab m...
Temozolomide
Lomustine
- 99 YearsAbbVie
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GlioblastomaNCT03970447
Glioblastoma
Temozolomide
Lomustine
Regorafenib
Radiation
Paxalisib
VAL-083
VT1021
Troriluzole
ADI-PEG 20
18 Years - Global Coalition for Adaptive Research
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing LossNCT05382338
Medulloblastoma
Cisplatin
Cyclophosphamid...
Lomustine
Mesna
Quality-of-Life...
Radiation Thera...
Sodium Thiosulf...
Survey Administ...
Vincristine
3 Years - 21 YearsChildren's Oncology Group
Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed GliomasNCT00278278
Brain and Centr...
cisplatin
etoposide
ifosfamide
lomustine
methotrexate
prednisone
vincristine sul...
3 Years - 18 YearsNational Cancer Institute (NCI)
Lomustine in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerNCT00293280
Lung Cancer
lomustine
18 Years - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent GlioblastomaNCT04863950
Glioblastoma
Lomustine
Imipramine Hydr...
- The University of Texas Health Science Center at San Antonio
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMNCT05902169
Glioblastoma
Recurrent Gliob...
GBM
SonoCloud-9 (SC...
Carboplatin
Lomustine
Temozolomide
18 Years - CarThera
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade GliomasNCT02343406
Glioblastoma
Depatuxizumab m...
Temozolomide
Lomustine
- 99 YearsAbbVie
Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central Nervous System LymphomaNCT00003929
Lymphoma
filgrastim
lomustine
procarbazine hy...
radiation thera...
- Case Comprehensive Cancer Center
Radiation Therapy Followed By Combination Chemotherapy in Treating Young Patients With Supratentorial Primitive Neuroectodermal TumorsNCT00274911
Brain and Centr...
cisplatin
lomustine
vincristine sul...
adjuvant therap...
radiation thera...
3 Years - 18 YearsNational Cancer Institute (NCI)
Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant GliomaNCT00006024
Brain Tumor
Central Nervous...
lomustine
temozolomide
3 Years - 21 YearsChildren's Oncology Group
Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade GliomaNCT00003375
Brain and Centr...
lomustine
procarbazine hy...
vincristine sul...
radiation thera...
18 Years - 120 YearsRadiation Therapy Oncology Group
Lomustine and Intermediate Dose Cytarabine in Older Patients With AMLNCT00480064
Acute Myeloid L...
Lomustine, inte...
60 Years - French Innovative Leukemia Organisation
Regorafenib in Relapsed GlioblastomaNCT02926222
Glioblastoma Mu...
Regorafenib
Lomustine
18 Years - Istituto Oncologico Veneto IRCCS
Phase Ib/II Study of Buparlisib Plus Carboplatin or Lomustine in Patients With Recurrent Glioblastoma MultiformeNCT01934361
Recurrent Gliob...
buparlisib
carboplatin
lomustine
placebo
18 Years - Novartis
A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With GlioblastomaNCT01860638
Glioblastoma
Bevacizumab
Lomustine
Placebo
Radiotherapy
Temozolomide
SOC Agent
18 Years - Hoffmann-La Roche
Regorafenib in Relapsed GlioblastomaNCT02926222
Glioblastoma Mu...
Regorafenib
Lomustine
18 Years - Istituto Oncologico Veneto IRCCS
A Study in Recurrent Glioblastoma (GB)NCT01582269
Glioblastoma
LY2157299 monoh...
Lomustine
Placebo
18 Years - Eli Lilly and Company
Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell LymphomaNCT00317408
Lymphoma
anti-thymocyte ...
busulfan
carboplatin
carmustine
cyclosporine
cytarabine
dexamethasone
etoposide phosp...
idarubicin
ifosfamide
leucovorin calc...
lomustine
melphalan
methotrexate
mitoxantrone hy...
prednisolone
thiotepa
vinblastine sul...
vindesine
allogeneic hema...
autologous hema...
peripheral bloo...
total-body irra...
- 21 YearsNational Cancer Institute (NCI)
Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell LymphomaNCT00317408
Lymphoma
anti-thymocyte ...
busulfan
carboplatin
carmustine
cyclosporine
cytarabine
dexamethasone
etoposide phosp...
idarubicin
ifosfamide
leucovorin calc...
lomustine
melphalan
methotrexate
mitoxantrone hy...
prednisolone
thiotepa
vinblastine sul...
vindesine
allogeneic hema...
autologous hema...
peripheral bloo...
total-body irra...
- 21 YearsNational Cancer Institute (NCI)
Combination Chemotherapy in Treating Children With Progressive Brain TumorsNCT00002944
Brain Tumors
Central Nervous...
carboplatin
lomustine
procarbazine hy...
thioguanine
vincristine sul...
- 9 YearsChildren's Oncology Group
Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed MedulloblastomaNCT00031590
Brain Tumors
Central Nervous...
Medulloblastoma
Cisplatin
Cyclophosphamid...
Etoposide
Lomustine
Vincristine
Craniospinal Ra...
3 Years - 30 YearsChildren's Hospital of Philadelphia
Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With MedulloblastomaNCT00058370
Brain and Centr...
cisplatin
lomustine
vincristine sul...
adjuvant therap...
iodine I 131 mo...
radiation thera...
3 Years - Memorial Sloan Kettering Cancer Center
Golden Halo, Static Magnetic and Electric Field Device, in Recurrent GlioblastomaNCT05410301
Glioblastoma
Recurrent Gliob...
Static Magnetic...
Lomustine
Bevacizumab
18 Years - University of Iowa
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated GlioblastomaNCT05095376
Glioblastoma
Gliosarcoma
Lomustine
Photon Beam Rad...
Quality-of-Life...
Questionnaire A...
Temozolomide
18 Years - 70 YearsNRG Oncology
6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma PatientsNCT00504660
Anaplastic Glio...
Glioblastoma Mu...
Brain Cancer
Capecitabine
Celecoxib (Cele...
Temozolomide
Lomustine
6-Thioguanine
12 Years - M.D. Anderson Cancer Center
Radiation Therapy Plus Combination Chemotherapy in Treating Children With MedulloblastomaNCT00053872
Brain and Centr...
cisplatin
lomustine
vincristine sul...
adjuvant therap...
radiation thera...
3 Years - 21 YearsNational Cancer Institute (NCI)
Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM SubjectsNCT03382977
Glioblastoma Mu...
VBI-1901
Carmustine
Lomustine
18 Years - VBI Vaccines Inc.
A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or RecurrenceNCT06336291
Glioblastoma
L19TNF
L19TNF
L19TNF
Lomustine
Lomustine
18 Years - Philogen S.p.A.
Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin's LymphomaNCT00049439
Lymphoma
filgrastim
cyclophosphamid...
etoposide
lomustine
procarbazine hy...
16 Years - Case Comprehensive Cancer Center
Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma PatientsNCT00527657
Brain Neoplasms
Melanoma
Lomustine
Temozolomide
Thalidomide
18 Years - M.D. Anderson Cancer Center
Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)NCT01067469
Brain Cancer
Glioblastoma
Standard Dose B...
Low Dose Bevaci...
Lomustine
18 Years - M.D. Anderson Cancer Center
Combination Chemotherapy and Bone Marrow Transplantation or Peripheral Stem Cell Transplantation in Treating Patients With OligodendrogliomaNCT00003101
Brain and Centr...
filgrastim
busulfan
lomustine
procarbazine hy...
thiotepa
vincristine sul...
autologous bone...
peripheral bloo...
18 Years - Memorial Sloan Kettering Cancer Center
A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With GlioblastomaNCT01860638
Glioblastoma
Bevacizumab
Lomustine
Placebo
Radiotherapy
Temozolomide
SOC Agent
18 Years - Hoffmann-La Roche
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) PatientsNCT02796261
Anaplastic Astr...
Recurrent Anapl...
Eflornithine
Lomustine
Lomustine
18 Years - Orbus Therapeutics, Inc.
Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)NCT01067469
Brain Cancer
Glioblastoma
Standard Dose B...
Low Dose Bevaci...
Lomustine
18 Years - M.D. Anderson Cancer Center
Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain TumourNCT00503204
Recurrent Gliob...
Brain Tumor
Cediranib
Lomustine
18 Years - AstraZeneca
9-ING-41 in Patients With Advanced CancersNCT03678883
Cancer
Pancreatic Canc...
Sarcoma
Renal Cancer
Refractory Canc...
Refractory Neop...
Refractory Non-...
Pancreatic Aden...
Resistant Cance...
Neoplasm Metast...
Neoplasm of Bon...
Neoplasm, Breas...
Neoplasm of Lun...
Neoplasms,Color...
Neoplasms Pancr...
Malignant Gliom...
Malignancies
Malignancies Mu...
Bone Metastases
Bone Neoplasm
Bone Cancer
Pancreas Cancer
Pancreatic Neop...
Breast Neoplasm...
Acute T Cell Le...
9-ING-41
Gemcitabine - 2...
Doxorubicin.
Lomustine
Carboplatin.
Nab paclitaxel.
Paclitaxel.
Gemcitabine - 2...
Irinotecan
18 Years - Actuate Therapeutics Inc.
Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary GlioblastomaNCT00761280
Anaplastic Astr...
Glioblastoma
trabedersen
temozolomide
Drug delivery s...
Placement of Dr...
carmustine
lomustine
18 Years - 70 YearsIsarna Therapeutics GmbH
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMNCT05902169
Glioblastoma
Recurrent Gliob...
GBM
SonoCloud-9 (SC...
Carboplatin
Lomustine
Temozolomide
18 Years - CarThera
Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain TumourNCT00503204
Recurrent Gliob...
Brain Tumor
Cediranib
Lomustine
18 Years - AstraZeneca
A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma MultiformeNCT03025893
Glioblastoma Mu...
Glioblastoma, A...
Glioblastoma
Recurrent Brain...
GBM
Sunitinib
Lomustine
18 Years - Amsterdam UMC, location VUmc
The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)NCT06283927
Glioblastoma
Glioblastoma Mu...
Glioblastoma, I...
Glioblastoma Mu...
Glioblastoma Mu...
Recurrent Gliob...
Astrocytoma, Ma...
Astrocytoma of ...
Re-resection
Temozolomide
Lomustine
Re-irradiation
Experimental th...
Best supportive...
18 Years - 90 YearsErasmus Medical Center
Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III StudyNCT05904119
First Progressi...
Lomustine
Reirradiation
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed MedulloblastomaNCT04402073
Medulloblastoma
Sonidegib
Cisplatin
Lomustine
Vincristine
radiotherapy
15 Years - European Organisation for Research and Treatment of Cancer - EORTC
Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant GliomaNCT00006024
Brain Tumor
Central Nervous...
lomustine
temozolomide
3 Years - 21 YearsChildren's Oncology Group
Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM)NCT00948389
Glioblastoma
Dasatinib
Lomustine
18 Years - Bristol-Myers Squibb
Lomustine in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerNCT00293280
Lung Cancer
lomustine
18 Years - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic AstrocytomaNCT03022578
IDH Family Wild...
Recurrent Anapl...
Recurrent Gliob...
Laser Interstit...
Lomustine
18 Years - M.D. Anderson Cancer Center
Combination Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin's LymphomaNCT00049439
Lymphoma
filgrastim
cyclophosphamid...
etoposide
lomustine
procarbazine hy...
16 Years - Case Comprehensive Cancer Center
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) PatientsNCT02796261
Anaplastic Astr...
Recurrent Anapl...
Eflornithine
Lomustine
Lomustine
18 Years - Orbus Therapeutics, Inc.
Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial GliomaNCT00002806
Brain and Centr...
lomustine
procarbazine hy...
vincristine sul...
low-LET photon ...
18 Years - Alliance for Clinical Trials in Oncology
Methotrexate, Procarbazine, Lomustine, Dexamethasone, and Cytarabine in Treating Patients With Primary CNS LymphomaNCT00074191
Lymphoma
cytarabine
dexamethasone
lomustine
methotrexate
procarbazine hy...
16 Years - 75 YearsOHSU Knight Cancer Institute
Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth GlioblastomaNCT04933942
First Progressi...
Lomustine
Romiplostim
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's LymphomasNCT00003113
Lymphoma
filgrastim
cyclophosphamid...
etoposide
lomustine
procarbazine hy...
radiation thera...
60 Years - Case Comprehensive Cancer Center
Monitoring Anti-angiogenic Therapy in Brain Tumors by Advanced MRINCT02843230
Glioblastoma
Avastin
Lomustine
Temozolomide
MRI
MRS
DSC
18 Years - Massachusetts General Hospital
Radiation Therapy Plus Combination Chemotherapy in Treating Children With MedulloblastomaNCT00002875
Brain Tumors
Central Nervous...
filgrastim
cisplatin
cyclophosphamid...
lomustine
mesna
vincristine sul...
low-LET electro...
low-LET photon ...
3 Years - 22 YearsChildren's Oncology Group
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing LossNCT05382338
Medulloblastoma
Cisplatin
Cyclophosphamid...
Lomustine
Mesna
Quality-of-Life...
Radiation Thera...
Sodium Thiosulf...
Survey Administ...
Vincristine
3 Years - 21 YearsChildren's Oncology Group
Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM)NCT00948389
Glioblastoma
Dasatinib
Lomustine
18 Years - Bristol-Myers Squibb
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