Spots Global Cancer Trial Database for locally advanced rectal carcinoma

Every month we try and update this database with for locally advanced rectal carcinoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation	NCT05610163	Locally Advance... Stage II Rectal... Stage III Recta...	Capecitabine 5-fluorouracil Leucovorin calc... Irinotecan Oxaliplatin Long Course Che... Computed Tomogr... Magnetic Resona... Sigmoidoscopy biopsy	18 Years -	Alliance for Clinical Trials in Oncology
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer	NCT05524012	Locally Advance... Neoadjuvant Tre... Radiotherapy Adaptive Treatm...	Blood sample MRI scan	18 Years -	Jena University Hospital
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer	NCT04406857	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage III Recta...	Capecitabine Radiation Thera... Ropidoxuridine	18 Years -	National Cancer Institute (NCI)
A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer: From a Multicenter Phase II Cohort to a Phase III Randomized Controlled Study	NCT06312982	Locally Advance...	Tislelizumab	18 Years - 75 Years	Beijing Friendship Hospital
Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer	NCT05622357	Locally Advance...	short course ra...	18 Years - 70 Years	National Cancer Institute, Egypt
Assessment of Efficacy of Neoadjuvant Therapy in Locally Advanced Rectal Cancer	NCT06314737	Locally Advance...		-	Sixth Affiliated Hospital, Sun Yat-sen University
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer	NCT06292975	Locally Advance...	Supervised Vigo...	18 Years -	University of Hull
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer	NCT04406857	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage III Recta...	Capecitabine Radiation Thera... Ropidoxuridine	18 Years -	National Cancer Institute (NCI)
Neoadjuvant Envafolimab in Resectable and Locally Advanced MSI-H/dMMR Rectal Cancer	NCT05645094	Locally Advance... MSI-High	Envafolimab	18 Years - 79 Years	Fudan University
MRI T1 Relaxation Time in Rectal Cancer	NCT05876026	Rectal Cancer Locally Advance...		18 Years -	Vejle Hospital
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer	NCT06292975	Locally Advance...	Supervised Vigo...	18 Years -	University of Hull
Multicenter Phase 2 Trial: a Tailored Strategy for Locally Advanced Rectal Carcinoma	NCT01333709	Locally Advance... Rectal Carcinom...	Induction trich... Early tumor res... Radiochemothera... Radiochemothera... Radical proctec...	18 Years -	Institut du Cancer de Montpellier - Val d'Aurelle
Resource-Sparing Curative Treatment for Rectal Cancer	NCT01459328	Rectal Carcinom...	Radiotherapy Radiotherapy	18 Years -	International Atomic Energy Agency
Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer	NCT05601505	Locally Advance... Circulating Tum...	circulating tum...	18 Years - 75 Years	Peking Union Medical College Hospital
Deep Learning Based MRI Radiomics in Predicting the Clinical Risk of Locally Advanced Rectal Cancer	NCT06314750	Locally Advance...		20 Years - 90 Years	Sixth Affiliated Hospital, Sun Yat-sen University
MRI T1 Relaxation Time in Rectal Cancer	NCT05876026	Rectal Cancer Locally Advance...		18 Years -	Vejle Hospital
Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers	NCT05722288	Localized Prost... Locally Advance... Locally Advance... Malignant Solid... Recurrent Prost... Stage I Prostat... Stage IB Cervic... Stage IB2 Cervi... Stage II Prosta... Stage II Rectal... Stage IIA Cervi... Stage IIB Cervi... Stage III Prost... Stage III Recta... Stage IIIA Cerv... Stage IIIB Cerv... Stage IIIC Cerv... Stage IVA Prost...	Biospecimen Col... Informational I... Quality-of-Life... Questionnaire A... Short-Term Fast...	18 Years -	City of Hope Medical Center
Deep Learning Based MRI Radiomics in Predicting the Clinical Risk of Locally Advanced Rectal Cancer	NCT06314750	Locally Advance...		20 Years - 90 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy	NCT06304597	Locally Advance...	Imfinzi Opdivo	18 Years -	University Medical Center Groningen
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision	NCT05772923	Organ Preservat... Rectal Cancer Quality of Life Locally Advance...	Contact x-ray b... Local excision	18 Years -	The Netherlands Cancer Institute
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer	NCT05731726	pMMR MSS MSI-L Locally Advance...	Serplilumab Capecitabine Oxaliplatin Celecoxib	18 Years - 75 Years	Zhejiang University
Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer	NCT03280277	Locally Advance... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Contrast-enhanc... Ferumoxytol	18 Years -	OHSU Knight Cancer Institute
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation	NCT05610163	Locally Advance... Stage II Rectal... Stage III Recta...	Capecitabine 5-fluorouracil Leucovorin calc... Irinotecan Oxaliplatin Long Course Che... Computed Tomogr... Magnetic Resona... Sigmoidoscopy biopsy	18 Years -	Alliance for Clinical Trials in Oncology
Endorectal Brachytherapy for Rectal Cancer	NCT05591534	Locally Advance...	Endorectal brac...	18 Years -	University Hospital, Bordeaux
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer	NCT05731726	pMMR MSS MSI-L Locally Advance...	Serplilumab Capecitabine Oxaliplatin Celecoxib	18 Years - 75 Years	Zhejiang University

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