Spots Global Cancer Trial Database for total mesorectal excision

Every month we try and update this database with for total mesorectal excision cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen	NCT04340401	Rectal Cancer	SHR-1210 Oxaliplatin Capecitabine Intensity modul... Total mesorecta...	18 Years - 70 Years	Peking University Cancer Hospital & Institute
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment	NCT05927584	Rectal Cancer Rectum Neoplasm	Transanal local...	18 Years -	Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer	NCT04301557	DMMR Colorectal... MSI-H Colorecta... Locally Advance...	PD-1 Antibody Oxaliplatin Capecitabine External beam r... Total mesorecta...	18 Years - 72 Years	Sun Yat-sen University
Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen	NCT04340401	Rectal Cancer	SHR-1210 Oxaliplatin Capecitabine Intensity modul... Total mesorecta...	18 Years - 70 Years	Peking University Cancer Hospital & Institute
THREE-row Circular STAPLER in Low Anterior Resection for Rectal Cancer	NCT03910699	Anastomotic Lea... Anastomotic Hae... Anastomotic Com... Rectal Neoplasm... Staple Misfire Anastomosis Anastomotic Ste...	Three-row circu... Two-row circula...	18 Years - 85 Years	Russian Society of Colorectal Surgeons
Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer	NCT01308190	Rectal Cancer	Capecitabine (X... 50.4 Gy Transanal Endos... Total Mesorecta...	18 Years -	Corporacion Parc Tauli
MRI Split Scar Sign as a Predictor to Complete Pathologic Response After Neoadjuvant Chemoradiation in Rectal Cancer	NCT04745091	Rectum Cancer	total mesorecta...	-	Alexandria University
PROSPECTIVE CONTROLLED AND RANDOMIZED STUDY OF THE GENITOURINARY FUNCTION AFTER RECTAL CANCER SURGERY IN RELATION TO THE DISSECTION OF THE INFERIOR MESENTERIC VESSELS	NCT03520088	Rectal Cancer	Inferior mesent... Inferior mesent...	18 Years - 100 Years	Corporacion Parc Tauli
Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer	NCT04296240	Rectal Cancer	Oxaliplatin and... Total Mesorecta...	18 Years - 80 Years	Peking University Cancer Hospital & Institute
Timing Evaluation of Stoma Closure (TIMES). Early vs Late Closure of Stoma After Rectal Cancer Surgery.	NCT05284864	Rectal Cancer Total Mesorecta... Ileostomy - Sto... Ileostomy; Comp... Ileostomy Closu...	Stoma closure	18 Years -	Hospital Universitario La Fe
The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer	NCT05984485	Rectal Cancer	neoadjuvant che... total mesorecta...	18 Years - 75 Years	Sun Yat-sen University
Laparoscopic Assisted Transanal Total Mesorectal Excision for Rectal Cancer in Low Site	NCT03253302	Rectal Cancer		18 Years - 80 Years	Beijing Friendship Hospital
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer	NCT02966483	Rectal Neoplasm... Surgery	TaTME LpTME	18 Years - 75 Years	Sun Yat-sen University
Minimally Invasive Sphincter Sparing Total Mesorectal Excision for Ultra-low Rectal Cancer After Initial Chemo-radiotherapy (MISS-TRICR).	NCT02488707	Rectal Cancer	laparoscopic in... Transanal minim...	18 Years -	Mansoura University
MRI Simulation-guided Boost in Short-course Preoperative Radiotherapy for Unresectable Rectal Cancer	NCT03714490	Rectal Neoplasm...	SCPRT CRT CAPOX	18 Years - 70 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer	NCT02966483	Rectal Neoplasm... Surgery	TaTME LpTME	18 Years - 75 Years	Sun Yat-sen University
RATME vs LATME in Middle and Low Rectal Cancer	NCT06105203	Total Mesorecta... Rectal Neoplasm... Robotic Surgica... Laparoscopy	Robotic-assiste... laparoscopic-as...	18 Years - 75 Years	The First Hospital of Jilin University
Total Neoadjuvant Induction and Consolidation CapeOX Plus IMRT With Capecitabine for MRI Defined High-risk Rectal Cancer	NCT02864849	Rectal Cancer	Oxaliplatin Capecitabine Intensity modul... Total mesorecta...	18 Years - 75 Years	Peking University Cancer Hospital & Institute
Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer	NCT04296240	Rectal Cancer	Oxaliplatin and... Total Mesorecta...	18 Years - 80 Years	Peking University Cancer Hospital & Institute
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer	NCT01308190	Rectal Cancer	Capecitabine (X... 50.4 Gy Transanal Endos... Total Mesorecta...	18 Years -	Corporacion Parc Tauli
Local Excision Versus Total Mesorectal Excision In Pathological Complete Response (ypT0-1cN0) Mid- Or Low-Rectal Cancer After Neoadjuvant Therapy	NCT03548844	Rectal Cancer Surgery	local excision total mesorecta...	18 Years - 75 Years	Sun Yat-sen University
Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma	NCT01302613	Stage II Rectal... Stage III Recta...	Capecitabine 5-FU Leucovorin Oxaliplatin radiation total mesorecta...	18 Years -	University of Texas Southwestern Medical Center
Pd1 Antibody Sintilimab ± Chemoradiotherapy for Locally Advanced Rectal Cancer	NCT04304209	Colorectal Canc... Colorectal Canc...	Oxaliplatin Capecitabine Sintilimab radiotherapy total mesorecta... Watch and wait	18 Years - 75 Years	Sun Yat-sen University
Total Neoadjuvant Therapy Followed by 'Watch and Wait' Approach or Organ Preservation for Low-risk Rectal Cancer	NCT04405206	Rectum Cancer	Oxaliplatin Capecitabine intensity modul... DRE-Endoscopy-M... Nonoperative Ma... Local excision Total Mesorecta... Quality of Life...	18 Years - 85 Years	Peking University Cancer Hospital & Institute
Local Excision Versus Total Mesorectal Excision In Pathological Complete Response (ypT0-1cN0) Mid- Or Low-Rectal Cancer After Neoadjuvant Therapy	NCT03548844	Rectal Cancer Surgery	local excision total mesorecta...	18 Years - 75 Years	Sun Yat-sen University
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital
MRI Features in Neoadjuvant Treatment Decisions for Patients With Rectal Cancer	NCT05609149	Rectal Cancer	total mesorecta...	18 Years - 80 Years	Sun Yat-sen University
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital
RATME vs LATME in Middle and Low Rectal Cancer	NCT06105203	Total Mesorecta... Rectal Neoplasm... Robotic Surgica... Laparoscopy	Robotic-assiste... laparoscopic-as...	18 Years - 75 Years	The First Hospital of Jilin University
Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients	NCT06314646	Rectal Cancer Surgery	Transanal Trans... Double-stapled ...	18 Years -	Istituto Clinico Humanitas
Local Excision in Downstaged Rectal Cancer	NCT00427375	Rectal Neoplasm...	local rectal ex... total mesorecta...	18 Years -	University Hospital, Bordeaux
Multicenter Study on Postoperative Urinary and Sexual Function During Laparoscopic Functional Total Mesorectum Excision	NCT05049317	Rectal Cancer	Laparoscopic FT...	18 Years - 70 Years	Renmin Hospital of Wuhan University
Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer	NCT04296240	Rectal Cancer	Oxaliplatin and... Total Mesorecta...	18 Years - 80 Years	Peking University Cancer Hospital & Institute
Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine Position	NCT02163785	Rectal Cancer Abdominoperinea...	Abdominoperinea...	18 Years -	Hospital Universitario La Fe
Robotic vs. TaTME Rectal Surgery (ROTA STUDY)	NCT04200027	Rectal Cancer	total mesorecta...	18 Years -	Odense University Hospital
Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer	NCT02533271	Cancer, Rectum	Short-course ra... Long-term chemo...	18 Years - 70 Years	ChineseAMS
Total Neoadjuvant Therapy Followed by 'Watch and Wait' Approach or Organ Preservation for Low-risk Rectal Cancer	NCT04405206	Rectum Cancer	Oxaliplatin Capecitabine intensity modul... DRE-Endoscopy-M... Nonoperative Ma... Local excision Total Mesorecta... Quality of Life...	18 Years - 85 Years	Peking University Cancer Hospital & Institute
Surgery Alone Versus Neoadjuvant Treatment Followed by Surgery For MRI-defined T3 Mid-low Rectal Cancer	NCT05496270	Rectal Cancer	total mesorecta...	18 Years - 80 Years	Sun Yat-sen University
Early-onset Rectal Cancer	NCT04496765	Rectal Cancer	Total mesorecta...	10 Years - 80 Years	Mansoura University
Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal Cancer	NCT02614157	Rectal Cancer	LLND labeled line	18 Years - 75 Years	West China Hospital
Total Neoadjuvant Treatment Plus SHR1210 for High-risk Rectal Cancer and Biomarker Screening Base on Neoantigen	NCT04340401	Rectal Cancer	SHR-1210 Oxaliplatin Capecitabine Intensity modul... Total mesorecta...	18 Years - 70 Years	Peking University Cancer Hospital & Institute
A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers	NCT05067413	Rectal Neoplasm...	Transanterior o... Total mesorecta...	18 Years - 80 Years	Peking University First Hospital
Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma	NCT03503630	Locally Advance...	COMPOUND 205526... Radiation Thera... mFOLFOX Total Mesorecta...	18 Years -	American University of Beirut Medical Center
Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer	NCT04751370	Locally Advance... Stage II Rectal... Stage III Recta...	Computed Tomogr... Ipilimumab Magnetic Resona... Nivolumab Radiation Thera... Sigmoidoscopy Total Mesorecta...	18 Years -	National Cancer Institute (NCI)
Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer	NCT00910143	Rectal Cancer	conventional re... total mesorecta...	16 Years -	Insel Gruppe AG, University Hospital Bern
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery	NCT05652361	Rectum Cancer	Additional visu...	18 Years -	Technische Universität Dresden
Surgery Alone Versus Neoadjuvant Treatment Followed by Surgery For MRI-defined T3 Mid-low Rectal Cancer	NCT05496270	Rectal Cancer	total mesorecta...	18 Years - 80 Years	Sun Yat-sen University
Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer	NCT04751370	Locally Advance... Stage II Rectal... Stage III Recta...	Computed Tomogr... Ipilimumab Magnetic Resona... Nivolumab Radiation Thera... Sigmoidoscopy Total Mesorecta...	18 Years -	National Cancer Institute (NCI)
Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal Cancer	NCT02614157	Rectal Cancer	LLND labeled line	18 Years - 75 Years	West China Hospital
A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers	NCT05067413	Rectal Neoplasm...	Transanterior o... Total mesorecta...	18 Years - 80 Years	Peking University First Hospital
The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer	NCT01421940	Rectal Cancer	Placebo drug Udenafil	20 Years - 65 Years	Kyungpook National University Hospital
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer	NCT04703101	Locally Advance... Rectal Adenocar... Stage II Rectal... Stage IIA Recta... Stage IIB Recta... Stage IIC Recta... Stage III Recta... Stage IIIA Rect... Stage IIIB Rect... Stage IIIC Rect...	Capecitabine Fluorouracil Intensity-Modul... Leucovorin Oxaliplatin Quality-of-Life... Surveillance Total Mesorecta...	18 Years -	Jonsson Comprehensive Cancer Center
Multicenter Phase II Study of Transanal TME (taTME)	NCT03144765	Rectal Cancer Surgery	Transanal Total...	18 Years -	Icahn School of Medicine at Mount Sinai
Local Excision in Downstaged Rectal Cancer	NCT00427375	Rectal Neoplasm...	local rectal ex... total mesorecta...	18 Years -	University Hospital, Bordeaux
Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management	NCT02008656	Rectal Cancer	Oxaliplatin (OX... 5-Fluorouracil ... Leucovorin Capecitabine (X... intensity modul... Quality of Life... DRE-Endoscopy	18 Years -	Memorial Sloan Kettering Cancer Center
Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma	NCT03503630	Locally Advance...	COMPOUND 205526... Radiation Thera... mFOLFOX Total Mesorecta...	18 Years -	American University of Beirut Medical Center
Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer	NCT00910143	Rectal Cancer	conventional re... total mesorecta...	16 Years -	Insel Gruppe AG, University Hospital Bern
Machine Learning-based Surgical Guidance System for Robot-assisted Rectal Surgery	NCT05652361	Rectum Cancer	Additional visu...	18 Years -	Technische Universität Dresden
Rectal Surgery Evaluation Trial (RESET)	NCT03574493	Rectal Cancer	TME with LAR	18 Years -	Institut du Cancer de Montpellier - Val d'Aurelle
Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer	NCT03359616	Rectal Cancer Surgery	Transanally cur... Laparoscopic to...	18 Years - 75 Years	Shanghai Minimally Invasive Surgery Center
Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma	NCT01302613	Stage II Rectal... Stage III Recta...	Capecitabine 5-FU Leucovorin Oxaliplatin radiation total mesorecta...	18 Years -	University of Texas Southwestern Medical Center
Intraoperative Monitoring of the Pelvic Autonomic Nerves	NCT01585727	Rectal Cancer	TME TME Neuromonitoring	18 Years - 90 Years	Johannes Gutenberg University Mainz
Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer	NCT06052332	Locally Advance... Older People	Short course ra... Adjuvant chemot... Total mesorecta... Total neoadjuva...	70 Years -	Jules Bordet Institute

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