Spots Global Cancer Trial Database for total neoadjuvant therapy

Every month we try and update this database with for total neoadjuvant therapy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE)	NCT05646511	Locally Advance...	SCRT CAPOX CAPOXIRI	18 Years -	National Cancer Center Hospital East
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer	NCT05939661	Rectal Cancer	Radiation Chemotherapy Surgery	18 Years -	Osaka University
A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Cancer	NCT05939661	Rectal Cancer	Radiation Chemotherapy Surgery	18 Years -	Osaka University
Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer	NCT05969847	Rectal Cancer	split-course hy... CAPOX Envafolimab Local excision	18 Years - 75 Years	Fujian Medical University Union Hospital
Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence	NCT05054959	Locally Advance...	consolidation c... induction chemo...	18 Years -	Institute of Oncology Ljubljana
Total Neoadjuvant Therapy for Adenocarcinoma of the OESophagus and Oesophagogastric Junction: TNT-OES-2 Trial	NCT06161818	Esophageal Canc... Adenocarcinoma ...	FLOT-CROSS or C...	18 Years - 74 Years	Erasmus Medical Center
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer	NCT05914766	Rectal Cancer Self Efficacy	PATHWAYS Enhanced usual ...	18 Years -	Massachusetts General Hospital
Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer	NCT06210971	Rectal Cancer	liposomal irino... Capecitabine Radiation threa...	18 Years - 80 Years	Hebei Medical University Fourth Hospital
Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer	NCT06097416	Rectal Cancer	Neoadjuvant Che... Total Neoadjuva...	18 Years -	St. James's Hospital, Ireland
Pilot Study of a Multimodal Prehabilitation Pancreatic Cancer Program	NCT03865875	Pancreatic Duct...	Exercise Progra... Nutrition Progr...	18 Years -	Massachusetts General Hospital
Total Neoadjuvant Therapy in Rectal Cancer Treatment	NCT04747951	Rectal Cancer	Concurrent Chem... TME consolidation c... adjuvant chemot...	18 Years -	State Scientific Centre of Coloproctology, Russian Federation
A Safety Study Adding Niraparib and Dostarlimab to Radiation Therapy for Rectal Cancers	NCT04926324	Rectal Neoplasm... Rectal Neoplasm...	Niraparib Dostarlimab Short course ra...	18 Years -	University of Iowa
Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer	NCT03170115	Rectal Cancer, ... Locally Advance... Chemoradiation	Aspirin Placebo Oral Ta...	18 Years - 75 Years	Instituto Nacional de Cancer, Brazil
Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer	NCT05601505	Locally Advance... Circulating Tum...	circulating tum...	18 Years - 75 Years	Peking Union Medical College Hospital
Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer	NCT06097416	Rectal Cancer	Neoadjuvant Che... Total Neoadjuva...	18 Years -	St. James's Hospital, Ireland
GEMCAD-REVEAL STUDY - Circulating Tumor DNA as a Predictor of Relapse in Patients With Locally Advanced Rectal Cancer.	NCT05674422	Patients With L...	total neoadjuva...	18 Years -	Grupo Espanol Multidisciplinario del Cancer Digestivo
Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence	NCT05054959	Locally Advance...	consolidation c... induction chemo...	18 Years -	Institute of Oncology Ljubljana
A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer	NCT04543695	Rectal Cancer	Concurrent Chem... XELOX mFOLFOX TME	18 Years - 75 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer	NCT04543695	Rectal Cancer	Concurrent Chem... XELOX mFOLFOX TME	18 Years - 75 Years	Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management	NCT02008656	Rectal Cancer	Oxaliplatin (OX... 5-Fluorouracil ... Leucovorin Capecitabine (X... intensity modul... Quality of Life... DRE-Endoscopy	18 Years -	Memorial Sloan Kettering Cancer Center
Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer	NCT06052332	Locally Advance... Older People	Short course ra... Adjuvant chemot... Total mesorecta... Total neoadjuva...	70 Years -	Jules Bordet Institute

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