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Spots Global Cancer Trial Database for checkpoint inhibitor

Every month we try and update this database with for checkpoint inhibitor cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study titleNCT IDConditionsInterventionsEligibilityOrganizationLink
TEIPP Immunotherapy in Patients With NSCLCNCT05898763
Non Small Cell ...
TEIPP24 (LRPAP7...
18 Years - Erasmus Medical Center
Study of the Safety and Efficacy of MIW815 With PDR001 in Patients With Advanced/Metastatic Solid Tumors or LymphomasNCT03172936
Solid Tumors an...
MIW815
PDR001
18 Years - Novartis
Durvalumab Long-Term Safety and Efficacy StudyNCT04078152
Solid Tumor
Durvalumab
18 Years - 130 YearsAstraZeneca
Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous MelanomaNCT02535078
Malignant Melan...
Tebentafusp (IM...
durvalumab
tremelimumab
18 Years - Immunocore Ltd
A Phase I/Ib Study of NIZ985 Alone and in Combination With SpartalizumabNCT04261439
In Escalation: ...
In Expansion: M...
NIZ985
Spartalizumab
Tislelizumab
18 Years - Novartis
Nivolumab Combined With Anlotinib as Re-challenge Treatment in Advanced NSCLCNCT04507906
NSCLC Stage IV
Checkpoint Inhi...
Nivolumab Combi...
18 Years - 75 YearsShanghai Chest Hospital
Postoperative Adjuvant Sintilimab in Hepatocellular Carcinoma With Microvascular InvasionNCT06089369
Hepatocellular ...
Sintilimab (9 c...
Sintilimab (18 ...
Active surveill...
18 Years - 75 YearsTongji Hospital
Identification of Pathways to Mitigate Immune-Related Adverse Events With Cancer ImmunotherapyNCT04283539
Cancer
systemic cortic...
18 Years - National Jewish Health
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid TumorsNCT03645928
Metastatic Mela...
Squamous Cell C...
Non-small Cell ...
Lifileucel
LN-145
Pembrolizumab
LN-145-S1
Ipilimumab
Nivolumab
12 Years - Iovance Biotherapeutics, Inc.
A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung CancerNCT04267237
Non-small Cell ...
Atezolizumab
RO7198457
18 Years - Hoffmann-La Roche
A Study of PSB205 in Subjects With Advanced Solid TumorsNCT03986606
Neoplasm Malign...
PSB205
18 Years - Qilu Puget Sound Biotherapeutics (dba Sound Biologics)
A Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Following Adjuvant Platinum-Doublet Chemotherapy in Participants Who Are ctDNA Positive After Surgical Resection of Stage II-III Non-Small Cell Lung CancerNCT04267237
Non-small Cell ...
Atezolizumab
RO7198457
18 Years - Hoffmann-La Roche
Neoadjuvant Durvalumab and Tremelimumab Plus Radiation for High Risk Soft-Tissue SarcomaNCT03116529
Soft Tissue Sar...
Combination Rad...
18 Years - University of Maryland, Baltimore
Preoperative Anti-PD-1 Antibody Combined With Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of EsophagusNCT03792347
Esophageal Squa...
Pembrolizumab
18 Years - 75 YearsRuijin Hospital
Melanoma Metastasized to the Brain and SteroidsNCT03563729
Malignant Melan...
Pembrolizumab I...
Ipilimumab Inje...
Nivolumab Injec...
Encorafenib
Binimetinib
Dabrafenib
Trametinib
18 Years - Herlev Hospital
A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung CancerNCT02439450
Non-small Cell ...
Viagenpumatucel...
Nivolumab
Pembrolizumab
Pemetrexed
18 Years - Heat Biologics
A Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder CancerNCT02897765
Urinary Bladder...
Bladder Tumors
Transitional Ce...
Malignant Melan...
Melanoma
Skin Cancer
Carcinoma, Non-...
Lung Cancer
NEO-PV-01
Nivolumab
Adjuvant
18 Years - BioNTech SE
Durvalumab for Advanced Hepatocellular Carcinoma in Patients With Active Chronic Hepatitis B Virus InfectionNCT04294498
Advanced Hepato...
Durvalumab
20 Years - National Taiwan University Hospital
Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant MesotheliomaNCT03644550
Mesothelioma
LMB-100
Pembrolizumab
18 Years - National Institutes of Health Clinical Center (CC)
A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707-101)NCT04009681
Metastasis
THOR-707
Checkpoint inhi...
anti-EGFR antib...
18 Years - Synthorx, Inc, a Sanofi company
Derazantinib and Atezolizumab in Patients With Urothelial CancerNCT04045613
Urothelial Carc...
Derazantinib 30...
Derazantinib 20...
Derazantinib 30...
Derazantinib 20...
Derazantinib 30...
Derazantinib 30...
Derazantinib 20...
18 Years - Basilea Pharmaceutica
Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension StudyNCT04924062
Biliary Tract C...
Pembrolizumab
Gemcitabine
Cisplatin
Placebo
18 Years - Merck Sharp & Dohme LLC
Neoadjuvant Toripalimab in Combination With Gemcitabine and Cisplatin Therapy in Local Advanced Bladder Cancer SubjectsNCT04861584
Urinary Bladder...
Neoadjuvant Tor...
18 Years - 75 YearsZhujiang Hospital
Neoadjuvant Durvalumab and Tremelimumab Plus Radiation for High Risk Soft-Tissue SarcomaNCT03116529
Soft Tissue Sar...
Combination Rad...
18 Years - University of Maryland, Baltimore
Hemopurifier Plus Pembrolizumab in Head and Neck CancerNCT04453046
Squamous Cell C...
Hemopurifier
Pembrolizumab 2...
18 Years - Aethlon Medical Inc.
Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLCNCT06173505
Nonsquamous Non...
Vudalimab + Car...
Pembrolizumab +...
18 Years - Xencor, Inc.
A Study of PSB205 in Subjects With Advanced Solid TumorsNCT03986606
Neoplasm Malign...
PSB205
18 Years - Qilu Puget Sound Biotherapeutics (dba Sound Biologics)
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid TumorsNCT03645928
Metastatic Mela...
Squamous Cell C...
Non-small Cell ...
Lifileucel
LN-145
Pembrolizumab
LN-145-S1
Ipilimumab
Nivolumab
12 Years - Iovance Biotherapeutics, Inc.
Development and Analysis of a Stool Bank for Cancer PatientsNCT04291755
Carcinoma, Non-...
Carcinoma, Colo...
Pembrolizumab I...
18 Years - Persephone Biosciences
Grapiprant and Pembrolizumab in Patients With Advanced or Progressive MSS Colorectal CancerNCT03658772
Microsatellite ...
grapiprant
grapiprant and ...
18 Years - Arrys Therapeutics
Study of the Safety and Efficacy of LHC165 Single Agent and in Combination With PDR001 in Patients With Advanced MalignanciesNCT03301896
Solid Tumors
LHC165
PDR001
18 Years - Novartis
A Personal Cancer Vaccine (NEO-PV-01) and APX005M or Ipilimumab With Nivolumab in Patients With Advanced MelanomaNCT03597282
Metastatic Mela...
NEO-PV-01
Nivolumab
Adjuvant
APX005M
ipilimumab
18 Years - BioNTech SE
Intratumoral CAVATAK (CVA21) and Pembrolizumab in Patients With Advanced Melanoma (VLA-011 CAPRA)NCT02565992
Melanoma
CAVATAK
Pembrolizumab
18 Years - Viralytics
FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid TumorsNCT03841110
Advanced Solid ...
Lymphoma
Gastric Cancer
Colorectal Canc...
Head and Neck C...
Squamous Cell C...
EGFR Positive S...
HER2-positive B...
Hepatocellular ...
Small Cell Lung...
Renal Cell Carc...
Pancreas Cancer
Melanoma
NSCLC
Urothelial Carc...
Cervical Cancer
Microsatellite ...
Merkel Cell Car...
FT500
Nivolumab
Pembrolizumab
Atezolizumab
Cyclophosphamid...
Fludarabine
IL-2
18 Years - Fate Therapeutics
Safety and Activity of PolyPEPI1018 Plus Atezolizumab in Colorectal Cancer.NCT05243862
Colorectal Canc...
PolyPEPI1018
Atezolizumab
18 Years - Treos Bio Limited
Melanoma Metastasized to the Brain and SteroidsNCT03563729
Malignant Melan...
Pembrolizumab I...
Ipilimumab Inje...
Nivolumab Injec...
Encorafenib
Binimetinib
Dabrafenib
Trametinib
18 Years - Herlev Hospital
Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant MesotheliomaNCT04840615
Mesothelioma
LMB-100
ipilimumab
Diphenhydramine
Famotidine
Acetaminophen
Dexamethasone
Biopsy
FDG-PET
CT CAP
MRI
ECG
Echocardiogram
18 Years - 120 YearsNational Institutes of Health Clinical Center (CC)
A Study of Combination Therapies With Viagenpumatucel-L (HS-110) in Patients With Non-Small Cell Lung CancerNCT02439450
Non-small Cell ...
Viagenpumatucel...
Nivolumab
Pembrolizumab
Pemetrexed
18 Years - Heat Biologics
Phase 3 Study of Sitravatinib Plus Nivolumab vs Docetaxel in Patients With Advanced Non-Squamous Non-Small Cell Lung CancerNCT03906071
Metastatic Non-...
Nivolumab
Sitravatinib
Docetaxel
18 Years - Mirati Therapeutics Inc.
Safety and Efficacy of Pembrolizumab (MK-3475) Versus Placebo as Adjuvant Therapy in Participants With Hepatocellular Carcinoma (HCC) and Complete Radiological Response After Surgical Resection or Local Ablation (MK-3475-937 / KEYNOTE-937)NCT03867084
Hepatocellular ...
Pembrolizumab
Placebo
18 Years - Merck Sharp & Dohme LLC
A Study Evaluating Safety and Therapeutic Activity of THOR-707 in Adult Subjects With Advanced or Metastatic Solid Tumors (THOR-707-101)NCT04009681
Metastasis
THOR-707
Checkpoint inhi...
anti-EGFR antib...
18 Years - Synthorx, Inc, a Sanofi company
Melanoma Metastasized to the Brain and SteroidsNCT03563729
Malignant Melan...
Pembrolizumab I...
Ipilimumab Inje...
Nivolumab Injec...
Encorafenib
Binimetinib
Dabrafenib
Trametinib
18 Years - Herlev Hospital
Atezolizumab Plus Tivozanib in Immunologically Cold Tumor TypesNCT05000294
Bile Duct Cance...
Gall Bladder Ca...
Breast Cancer
Neuroendocrine ...
Ovarian Cancer
Pancreatic Aden...
Soft Tissue Sar...
Vulvar Cancer
Prostate Cancer
Atezolizumab
Tivozanib
18 Years - 99 YearsUniversity of Florida
A Phase I/Ib Study of NIZ985 Alone and in Combination With SpartalizumabNCT04261439
In Escalation: ...
In Expansion: M...
NIZ985
Spartalizumab
Tislelizumab
18 Years - Novartis
Neoadjuvant Ipilimumab Plus Nivolumab Versus Standard Adjuvant Nivolumab in Macroscopic Stage III MelanomaNCT04949113
Malignant Melan...
Neoadjuvant ipi...
Adjuvant nivolu...
16 Years - The Netherlands Cancer Institute
A Study of ONCOS-102 in Combination With Other Novel Immune-therapies in Advanced Treatment-resistant Melanoma PatientsNCT05561491
Melanoma
ONCOS-102
Balstilimab
18 Years - Targovax ASA
Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)NCT04003636
Biliary Tract C...
Pembrolizumab
Gemcitabine
Cisplatin
Placebo
18 Years - Merck Sharp & Dohme LLC
PARP Inhibition, Stereotactic Body Radiotherapy and Immunotherapy for Metastatic or Advanced Sarcoma (PRIMA)NCT06074692
Sarcoma
Sarcoma,Soft Ti...
Sarcoma of Bone
Camrelizumab an...
10 Years - 70 YearsRuijin Hospital
ARGONAUT: Stool and Blood Sample Bank for Cancer PatientsNCT04638751
Non-small Cell ...
Colorectal Canc...
Triple Negative...
Pancreas Cancer
Immunotherapy
Chemotherapy
CRC surgical re...
Colonoscopy
18 Years - Persephone Biosciences
Nivolumab Combined With Anlotinib as Re-challenge Treatment in Advanced NSCLCNCT04507906
NSCLC Stage IV
Checkpoint Inhi...
Nivolumab Combi...
18 Years - 75 YearsShanghai Chest Hospital
INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)NCT03491683
Glioblastoma
INO-5401
INO-9012
Cemiplimab
Radiation Thera...
Temozolomide
18 Years - Inovio Pharmaceuticals
A Study of ONCOS-102 in Combination With Other Novel Immune-therapies in Advanced Treatment-resistant Melanoma PatientsNCT05561491
Melanoma
ONCOS-102
Balstilimab
18 Years - Targovax ASA
A Phase I/Ib Study of NIZ985 Alone and in Combination With SpartalizumabNCT04261439
In Escalation: ...
In Expansion: M...
NIZ985
Spartalizumab
Tislelizumab
18 Years - Novartis
A Personal Cancer Vaccine (NEO-PV-01) With Pembrolizumab and Chemotherapy for Patients With Lung CancerNCT03380871
Carcinoma, Non-...
Lung Cancer
Nonsquamous Non...
NEO-PV-01
Pembrolizumab
Adjuvant
Carboplatin
Pemetrexed
18 Years - BioNTech SE
Talimogene Laherparepvec With Pembrolizumab in Melanoma Following Progression on Prior Anti-PD-1 Based Therapy (MASTERKEY-115) (Mk-3475-A07/KEYNOTE-A07).NCT04068181
Melanoma
Talimogene lahe...
Pembrolizumab
18 Years - 99 YearsAmgen
Checkpoint Inhibitors in Patients With Solid Tumors: a Retrospective Real-world StudyNCT05719324
Immunotherapy
18 Years - The First Affiliated Hospital with Nanjing Medical University
9-ING-41 in Patients With Advanced CancersNCT03678883
Cancer
Pancreatic Canc...
Sarcoma
Renal Cancer
Refractory Canc...
Refractory Neop...
Refractory Non-...
Pancreatic Aden...
Resistant Cance...
Neoplasm Metast...
Neoplasm of Bon...
Neoplasm, Breas...
Neoplasm of Lun...
Neoplasms,Color...
Neoplasms Pancr...
Malignant Gliom...
Malignancies
Malignancies Mu...
Bone Metastases
Bone Neoplasm
Bone Cancer
Pancreas Cancer
Pancreatic Neop...
Breast Neoplasm...
Acute T Cell Le...
9-ING-41
Gemcitabine - 2...
Doxorubicin.
Lomustine
Carboplatin.
Nab paclitaxel.
Paclitaxel.
Gemcitabine - 2...
Irinotecan
18 Years - Actuate Therapeutics Inc.
Study of SRF617 With AB928 (Etrumadenant) and AB122 (Zimberelimab) in Patients With Metastatic Castration Resistant Prostate CancerNCT05177770
Metastatic Cast...
Prostate Cancer
SRF617
etrumadenant
zimberelimab
18 Years - Coherus Biosciences, Inc.
Breast Cancer Study of Preoperative Pembrolizumab + RadiationNCT03366844
Breast Cancer
Pembrolizumab
RT Boost
18 Years - Cedars-Sinai Medical Center
Breast Cancer Study of Preoperative Pembrolizumab + RadiationNCT03366844
Breast Cancer
Pembrolizumab
RT Boost
18 Years - Cedars-Sinai Medical Center
Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant MesotheliomaNCT03644550
Mesothelioma
LMB-100
Pembrolizumab
18 Years - National Institutes of Health Clinical Center (CC)
Checkpoint Inhibitors in Patients With Cancer and Underlying Autoimmune DiseaseNCT04805099
Autoimmune Dise...
Checkpoint Inhi...
Immunotherapy
Checkpoint inhi...
18 Years - Hellenic Cooperative Oncology Group
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid TumorNCT04042116
Advanced Solid ...
Gynecologic Can...
Lucitanib
Lucitanib
Lucitanib
Nivolumab
18 Years - Clovis Oncology, Inc.
Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT)NCT04574583
Metastatic Canc...
Solid Tumors
SX-682
M7824
MVA-BN-CV301
recombinant fow...
18 Years - National Institutes of Health Clinical Center (CC)
Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal CarcinomaNCT04995120
Laryngeal Cance...
Hypopharynx Can...
Laryngeal Neopl...
chemotherapy TP...
18 Years - 75 YearsFudan University
Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory CancersNCT03388632
Metastatic Soli...
Treatment-Refra...
rhIL-15
Ipilimumab
Nivolumab
18 Years - National Institutes of Health Clinical Center (CC)
Combination Immunotherapy in Biochemically Recurrent Prostate CancerNCT03315871
Prostate Cancer
PROSTVAC-V
PROSTVAC-F
MSB0011359C (M7...
CV301
18 Years - National Institutes of Health Clinical Center (CC)
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 InactivationNCT04104893
Metastatic Cast...
Pembrolizumab
18 Years - VA Office of Research and Development
A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid TumorNCT04042116
Advanced Solid ...
Gynecologic Can...
Lucitanib
Lucitanib
Lucitanib
Nivolumab
18 Years - Clovis Oncology, Inc.
LMB-100 Followed by Pembrolizumab in the Treatment of Adults With Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)NCT04027946
Lung Cancer
Non-Small Cell ...
Adenocarcinoma ...
LMB-100
pembrolizumab
Mesothelin Expr...
TrueSight Oncol...
18 Years - National Institutes of Health Clinical Center (CC)
Study of SRF617 With AB928 (Etrumadenant) and AB122 (Zimberelimab) in Patients With Metastatic Castration Resistant Prostate CancerNCT05177770
Metastatic Cast...
Prostate Cancer
SRF617
etrumadenant
zimberelimab
18 Years - Coherus Biosciences, Inc.
Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for RecurrenceNCT04410445
Melanoma
Melanoma Stage ...
Melanoma Stage ...
Melanoma (Skin)
Bempegaldesleuk...
Nivolumab
12 Years - Nektar Therapeutics
A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 InactivationNCT04104893
Metastatic Cast...
Pembrolizumab
18 Years - VA Office of Research and Development
Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck CancerNCT05472506
Head and Neck S...
Head and Neck C...
Head Cancer
Neck Cancer
Head Cancer Nec...
Neck Carcinoma
IK-175 + nivolu...
18 Years - Ikena Oncology
Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD-1-refractory/Relapsed, Unresectable Stage III or IV MelanomaNCT04526899
Melanoma Stage ...
Melanoma Stage ...
Unresectable Me...
BNT111
Cemiplimab
18 Years - BioNTech SE
Study of the Safety and Efficacy of MIW815 With PDR001 in Patients With Advanced/Metastatic Solid Tumors or LymphomasNCT03172936
Solid Tumors an...
MIW815
PDR001
18 Years - Novartis
Safety and Efficacy of PD-1 Inhibitors in Patients With Liver TransplantNCT03966209
Hepatocellular ...
Liver Transplan...
JS001(PD-1 inhi...
18 Years - 70 YearsShanghai Zhongshan Hospital
Talimogene Laherparepvec With Pembrolizumab in Melanoma Following Progression on Prior Anti-PD-1 Based Therapy (MASTERKEY-115) (Mk-3475-A07/KEYNOTE-A07).NCT04068181
Melanoma
Talimogene lahe...
Pembrolizumab
18 Years - 99 YearsAmgen
Derazantinib and Atezolizumab in Patients With Urothelial CancerNCT04045613
Urothelial Carc...
Derazantinib 30...
Derazantinib 20...
Derazantinib 30...
Derazantinib 20...
Derazantinib 30...
Derazantinib 30...
Derazantinib 20...
18 Years - Basilea Pharmaceutica
A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic TumorsNCT06188208
Advanced Solid ...
Advanced Hemato...
VVD-130850
Pembrolizumab
18 Years - Vividion Therapeutics, Inc.
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