Spots Global Cancer Trial Database for neoadjuvant chemoradiotherapy

Every month we try and update this database with for neoadjuvant chemoradiotherapy cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI Guided Radiotherapy	NCT04815694	Neoadjuvant Che... Locally Advance... Pathological Co...	RT Dose escalat...	18 Years -	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer	NCT02031939	Advanced Rectal...	Induction chemo... standard chemor...	18 Years - 75 Years	Sun Yat-sen University
Multimodal Functional Imaging Combined With Metabolomics in Predicting the Efficacy of nCRT for Locally Advanced ESCC	NCT04759235	Esophageal Squa...	Magnetic resona... 18F-Fluorodeoxy... Blood and urine...	18 Years - 75 Years	RenJi Hospital
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Additional Chemotherapy After Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer	NCT01671683	Rectal Cancer		20 Years - 90 Years	Chungnam National University
RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus	NCT00559351	Esophageal Neop... Squamous Cell C...	transthoracic e... neoadjuvant che... neoadjuvant che...	18 Years - 75 Years	Ministry of Scientific Research and Information Technology, Poland
Phase II Trial of Regimen for Stage III (N2) NSCLC Using Induction Treatment Followed by Resection	NCT01926483	Non-small Cell ...	Neoadjuvant Che...	18 Years - 65 Years	Zhejiang Cancer Hospital
Preoperative Anti-PD-1 Antibody Combined With Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus	NCT03792347	Esophageal Squa...	Pembrolizumab	18 Years - 75 Years	Ruijin Hospital
Neoadjuvant Immunotherapy Plus CRT Versus Neoadjuvant CRT for Locally Advanced Resectable ESCC	NCT04973306	Esophageal Squa... Esophageal Squa...	Neoadjuvant Che... Tislelizumab Ivor-Lewis or M...	18 Years - 75 Years	Shanghai Zhongshan Hospital
Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer	NCT01899118	Locally Advance...	Preoperative ir... Nimotuzumab Oxaliplatin Capecitabine	18 Years - 75 Years	Zhejiang Cancer Hospital
Neoadjuvant Chemoradiotherapy vs. Chemotherapy With Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer	NCT01815853	Gastric Cancer	Neoadjuvant Che... Neoadjuvant Che... R0 D2 Gastrecto... Adjuvant Chemot...	18 Years - 75 Years	Sun Yat-sen University
UGT1A1 Combined With Pharmacokinetics of SN-38 in CPT-11-based CRT in Patients With Advanced Rectal Cancer	NCT03824899	Locally Advance...	Blood concentra...	18 Years - 75 Years	Fudan University
Comparison Between NCRT and NCT Followed by MIE for Treatment of Locally Advanced Resectable ESCC	NCT03001596	Esophageal Squa...	Neoadjuvant Che... Neoadjuvant Che... Minimally Invas...	18 Years - 75 Years	Shanghai Zhongshan Hospital
Neoadjuvant Sintilimab Plus Chemoradiotherapy for Locally Advanced Adenocarcinoma of Esophagogastric Junction	NCT06250894	PD-1 Neoadjuvant Che... Gastroesophagea...	PD-1inhibitor	18 Years - 70 Years	Wuhan Union Hospital, China
Prediction of Response to Neoadjuvant Therapy in Rectal Cancer	NCT02439086	Rectal Neoplasm...	PET-CT Scan	-	Colchester General Hospital
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Neoadjuvant Chemoradiotherapy vs. Chemotherapy With Radical Gastrectomy and Adjuvant Chemotherapy for Advanced Gastric Cancer	NCT01815853	Gastric Cancer	Neoadjuvant Che... Neoadjuvant Che... R0 D2 Gastrecto... Adjuvant Chemot...	18 Years - 75 Years	Sun Yat-sen University
RadioPathomics Artificial Intelligence Model to Predict Tumor Regression Grading in Locally Advanced Rectal Cancer	NCT04273451	Rectal Cancer		18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer	NCT05148767	Rectal Cancer S...	Neoadjuvant che...	18 Years - 75 Years	Zhejiang Cancer Hospital
Surveillance of Peripheral Blood of Lymphocyte and Immunocyte in Neoadjuvant Therapy Patients With Esophageal Squamous Cell Carcinoma (pLINE)	NCT04440332	Esophageal Squa... Neoadjuvant The... Surgery		18 Years - 80 Years	Sichuan Cancer Hospital and Research Institute
Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Chemotherapy For Unresectable Locally Advanced Colon Cancer	NCT03970694	Colon Cancer	Radiotherapy oxaliplatin+cap...	18 Years - 70 Years	Sun Yat-sen University
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer	NCT05148767	Rectal Cancer S...	Neoadjuvant che...	18 Years - 75 Years	Zhejiang Cancer Hospital
Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer	NCT06097416	Rectal Cancer	Neoadjuvant Che... Total Neoadjuva...	18 Years -	St. James's Hospital, Ireland
Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology	NCT05969938	Rectal Adenocar... Circulating Tum... Minimal Residua... Neoadjuvant Che...	MRD detection	18 Years - 75 Years	Sun Yat-sen University
Radiation-protection Effect of Amifostine in Locally Advanced Rectal Cancer	NCT03702985	Locally Advance...	Radiation Capecitabine Irinotecan Amifostine	18 Years - 75 Years	Fudan University
Randomized Controlled Study on Optimize Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer	NCT02031939	Advanced Rectal...	Induction chemo... standard chemor...	18 Years - 75 Years	Sun Yat-sen University
Preoperative Concurrent Chemoradiotherapy for Locally Advanced Gastroesophageal Junction or Upper Gastric Adenocarcinoma	NCT02193594	Gastroesophagea...	Preoperative co... Radical D2 tota... Adjuvant chemot...	18 Years - 80 Years	Peking University
Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）	NCT04027543	Radiotherapy Si... Chemotherapy Ef... Oesophageal Car... Effect of Drugs Safety Issues	Neoadjuvant che... Oesophagectomy Neoadjuvant che...	18 Years - 80 Years	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Total Neoadjuvant Treatment for pMMR Locally Advanced Low Rectal Cancer: Anti-PD-1 Antibody With FOLFOXIRI and Preoperative Radiation Therapy	NCT06099951	Colorectal Canc...	Serplulimab + F... Radiation thera...	18 Years - 75 Years	Sun Yat-sen University
A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk	NCT04664504	Rectal Cancer	Concurrent Chem... Short-course Ra... Local dose incr... Consolidation c... Adjuvant chemot... TME	18 Years - 75 Years	ChineseAMS
Dendrobium Huoshanense Suppository in Rectal Cancer	NCT05079438	Locally Advance...	Dendrobium Huos...	18 Years - 75 Years	Zhejiang Cancer Hospital
Pre-operative Chemotherapy Versus Concurrent Chemoradiotherapy in Locally Advanced Non-small Cell Lung Cancer	NCT01054482	Non-small Cell ...	Pre-operative c... Pre-operative c...	18 Years - 85 Years	The First Affiliated Hospital of Guangzhou Medical University
Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer	NCT05601505	Locally Advance... Circulating Tum...	circulating tum...	18 Years - 75 Years	Peking Union Medical College Hospital
Neoadjuvant Versus Adjuvant Therapy in Treating Resectable Thoracic Esophageal Cancer	NCT01463501	Esophageal Canc...	Neoadjuvant che... Adjuvant chemor...	18 Years - 65 Years	Zhejiang Cancer Hospital
Comparison Between NCRT and NCT Followed by MIE for Treatment of Locally Advanced Resectable ESCC	NCT03001596	Esophageal Squa...	Neoadjuvant Che... Neoadjuvant Che... Minimally Invas...	18 Years - 75 Years	Shanghai Zhongshan Hospital
Multimodal Functional Imaging Combined With Metabolomics in Predicting the Efficacy of nCRT for Locally Advanced ESCC	NCT04759235	Esophageal Squa...	Magnetic resona... 18F-Fluorodeoxy... Blood and urine...	18 Years - 75 Years	RenJi Hospital
Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer	NCT06097416	Rectal Cancer	Neoadjuvant Che... Total Neoadjuva...	18 Years -	St. James's Hospital, Ireland
Preoperative Chemoradiotherapy Versus Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases	NCT01187290	Non-small Cell ...	neoadjuvant che...	18 Years - 75 Years	Shanghai Jiao Tong University School of Medicine
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer	NCT04460352	Esophageal Squa...	Neoadjuvant rad... Carboplatin, pa... Esophagectomy Neoadjuvant rad... Carboplatin, pa... Cisplatin, pacl... Oxaliplatin, ca... Esophagectomy	18 Years - 80 Years	Karolinska University Hospital
Pembrolizumab Plus Neoadjuvant Chemotherapy vs. Neoadjuvant Chemoradiotherapy for Locally Advanced ESCC (KEYSTONE-002)	NCT04807673	Esophageal Squa...	Pembrolizumab Paclitaxel Cisplatin neoadjuvant che...	18 Years - 75 Years	Tianjin Medical University Cancer Institute and Hospital
Neoadjuvant Immunotherapy Plus CRT Versus Neoadjuvant CRT for Locally Advanced Resectable ESCC	NCT04973306	Esophageal Squa... Esophageal Squa...	Neoadjuvant Che... Tislelizumab Ivor-Lewis or M...	18 Years - 75 Years	Shanghai Zhongshan Hospital
Pre-Surgery If Needed for Oesophageal Cancer	NCT03937362	Esophageal Canc...	First clinical ... Second clinical...	20 Years -	Shanghai Chest Hospital
Preoperative Chemoradiotherapy Versus Chemotherapy Alone in Nonsmall Cell Lung Cancer (NSCLC) Patients With Mediastinal Lymph Node Metastases	NCT01187290	Non-small Cell ...	neoadjuvant che...	18 Years - 75 Years	Shanghai Jiao Tong University School of Medicine
Prediction of Response to Neoadjuvant Therapy in Rectal Cancer	NCT02439086	Rectal Neoplasm...	PET-CT Scan	-	Colchester General Hospital
Surgery Without Neoadjuvant Chemoradiotherapy Compared With Neoadjuvant Chemoradiotherapy for Rectal Cancer With Negative Circumferential Resection Margin Based on MRI Assessment, a Perspective Multicenter Randomized Controlled Trial	NCT03504449	Circumferential... Intraoperative ... Local Recurrenc... Disease-free Su... Overal Survival	neoadjuvant che...	18 Years - 75 Years	Beijing Chao Yang Hospital
A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced Rectal Cancer	NCT04394598	Locally Advance...	Dendrobium Huos... Pelvic Radiatio... Capecitabine Irinotecan Placebo	18 Years - 70 Years	Fudan University
Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology	NCT05969938	Rectal Adenocar... Circulating Tum... Minimal Residua... Neoadjuvant Che...	MRD detection	18 Years - 75 Years	Sun Yat-sen University
A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced Rectal Cancer	NCT04394598	Locally Advance...	Dendrobium Huos... Pelvic Radiatio... Capecitabine Irinotecan Placebo	18 Years - 70 Years	Fudan University
Outcomes of Resection at Different Times Between the End of Neoadjuvant Treatment and Surgery	NCT04013347	Neoadjuvant Che... Rectal Tumor Surgery Surgery--Compli...	Rectal Resectio...	18 Years - 90 Years	Campus Bio-Medico University
The Analysis of Immuno-Nutrition Index in Advanced Gastric Cancer Receiving Preoperative Treatments	NCT03493880	Gastric Cancer Neoadjuvant Che... Neoadjuvant Che... Systemic Inflam... Nutrition Aspec...		-	Peking University
Neoadjuvant Sintilimab Plus Chemoradiotherapy for Locally Advanced Adenocarcinoma of Esophagogastric Junction	NCT06250894	PD-1 Neoadjuvant Che... Gastroesophagea...	PD-1inhibitor	18 Years - 70 Years	Wuhan Union Hospital, China
RadioPathomics Artificial Intelligence Model to Predict nCRT Response in Locally Advanced Rectal Cancer	NCT04271657	Rectal Cancer		18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus	NCT00559351	Esophageal Neop... Squamous Cell C...	transthoracic e... neoadjuvant che... neoadjuvant che...	18 Years - 75 Years	Ministry of Scientific Research and Information Technology, Poland
Surgery Without Neoadjuvant Chemoradiotherapy Compared With Neoadjuvant Chemoradiotherapy for Rectal Cancer With Negative Circumferential Resection Margin Based on MRI Assessment, a Perspective Multicenter Randomized Controlled Trial	NCT03504449	Circumferential... Intraoperative ... Local Recurrenc... Disease-free Su... Overal Survival	neoadjuvant che...	18 Years - 75 Years	Beijing Chao Yang Hospital
Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）	NCT04027543	Radiotherapy Si... Chemotherapy Ef... Oesophageal Car... Effect of Drugs Safety Issues	Neoadjuvant che... Oesophagectomy Neoadjuvant che...	18 Years - 80 Years	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Radiomics-based Artificial Intelligence System to Predict Neoadjuvant Treatment Response in Rectal Cancer	NCT04273477	Rectal Cancer		18 Years - 75 Years	Sixth Affiliated Hospital, Sun Yat-sen University
Neoadjuvant Chemoradiotherapy Versus Neoadjuvant Chemotherapy For Unresectable Locally Advanced Colon Cancer	NCT03970694	Colon Cancer	Radiotherapy oxaliplatin+cap...	18 Years - 70 Years	Sun Yat-sen University
A Phase II Study of Total Neoadjuvant Therapy for Locally Advanced Gastric Cancer	NCT04062058	Gastric Cancer Neoadjuvant The...	SIB-IMRT S-1 SOX Surgery	18 Years - 75 Years	ChineseAMS
Observational Study on the Patients With Rectal Cancer	NCT02312284	Rectal Cancer Adjuvant Chemor... Neoadjuvant Che... Adjuvant Chemot... Surgery		18 Years -	ChineseAMS
Neoadjuvant Versus Adjuvant Therapy in Treating Resectable Thoracic Esophageal Cancer	NCT01463501	Esophageal Canc...	Neoadjuvant che... Adjuvant chemor...	18 Years - 65 Years	Zhejiang Cancer Hospital
Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer	NCT05228431	Advanced Rectal...	XELOX Capecitabine mo... Radiation	18 Years - 75 Years	Sun Yat-sen University
Pre-Surgery If Needed for Oesophageal Cancer	NCT03937362	Esophageal Canc...	First clinical ... Second clinical...	20 Years -	Shanghai Chest Hospital

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